Fluocinonide 99.0% Solid Dideu
GMP HALAL KOSHER ISO FDA
356-12-7
Industrial Grade
99%
Dideu
25kg/Drum
2022-12-26
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceFluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders.Target: Glucocorticoid ReceptorFluocinonide is a potent glucocorticoid steroid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. Fluocinonide ranks as a "high-potency" topical corticosteroid. Minimal amounts should be used for a minimal length of time to avoid the occurrence of adver
Solid
Fluocinonide is an organic molecular entity.|A topical glucocorticoid used in the treatment of eczema.|Fluocinonide is a Corticosteroid. The mechanism of action of fluocinonide is as a Corticosteroid Hormone Receptor Agonist.|Fluocinonide is a synthetic glucocorticoid and derivative of fluocinolone acetonide with anti-inflammatory and antipruritic activities. Fluocinonide binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinonide that interacts and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinonide binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis.|A topical glucocorticoid used in the treatment of ECZEMA.CertificatesBasic Info-
Product Name:
Fluocinonide
Other Name:Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(6α,11β,16α)-;Pregna-1,4-diene-3,20-dione,6α,9-difluoro-11β,16α,17,21-tetrahydroxy-,cyclic 16,17-acetal with acetone,21-acetate;2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole,pregna-1,4-diene-3,20-dione deriv.;(6α,11β,16α)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;Fluocinolone acetonide acetate;Fluocinolide;Fluocinonide;Fluocinolone acetonide 21-acetate;Metosyn;Lidex E;Fluocinolide acetate;Flucinar;Topsym;Lidex;Topsymin;NSC 101791;Topsyne;Straderm;Dermaplus;Topsyn;Biscosal;Flucetonide;Vanos
CAS No.:356-12-7
Molecular Formula:C26H32F2O7
InChIKeys:InChIKey=WJOHZNCJWYWUJD-IUGZLZTKSA-N
Molecular Weight:494.52
Exact Mass:494.52
EC Number:206-597-6
UNII:2W4A77YPAN
DSSTox ID:DTXSID8045307
NCI Thesaurus Code:C29056
ATC Code:C - Cardiovascular system|D - Dermatologicals
HScode:2937210000
Categories:
Characteristics-
PSA:
99.13000
XLogP3:3.36
Appearance:white to tan
Density:1.3±0.1 g/cm3
Melting Point:309 °C
Boiling Point:591.1±50.0 °C at 760 mmHg
Flash Point:311.3±30.1 °C
Refractive Index:1.560
Water Solubility:DMSO: ≥19mg/mL
Storage Conditions:Refrigerator
Specific rotation:D +83° (chloroform)
Collision Cross Section:229.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 2, Oral
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H300 Fatal if swallowed
H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
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Certifications:
ISO Certificate,REACH
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