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Edoxaban powder 99% Purity 480449-70-5 99% white powder 480449-70-5 buy - image1

Edoxaban powder 99% Purity 480449-70-5 99% white powder 480449-70-5

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CAS No.:

480449-70-5

Grade:

Pharmaceutical Grade

Content:

99%

Port:

beijing/shanghai

Packaging:

25kg/drum

Price valid (until):

2023-06-03

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Jinan Million Pharmaceutical Co., Ltd

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Avanafil,Tirzepatide,Semaglutide,Pregabalin,Nootropics,MT2

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Product Description
Seller Information
Inquiry History

Description

Product Detail

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Product name: Edoxabn

Cas NO.: 480449-70-5

M.F: C24H30ClN7O4S

M.W.: 548.06

Capacity: 80KG/M

Usage: Cerebro-cardiovascular

Product introduce:

General: Edoxabn is a reversible factor Xa inhibitor with high selectivity. During coagulation, factor Xa forms a prothrombinase complex with factor Va on the surface of platelets . Prothrombinase converts prothrombin to thrombin, which in turn converts soluble fibrinogen to insoluble fibrin, the main component of blood clots. Thus, FXa has become a major target for the development of a new generation of anticoagulants.

Product introduce：Edoxabn is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.

Function： Edo xaban can be used to prevent serious blood clots from forming due to some irregular heartbeat (atrial fibrillation). It is also used to treat certain blood clots. It is an anticoagulant, which works by blocking some coagulation proteins in the blood.

Origin: On January 8, 2015, the US Food and Drug Administration (FDA) approved a brand, an anticoagulant drug from the Daiichi Sankyo Company Limited，TYO: 4568 , to reduce the risk of stroke and dangerous thrombosis (systemic embolism) in patients with atrial fibrillation caused by non-valvular heart disease.

Researchers led by Dr. Robert Giugliano, a cardiologist at Boston brigham Women's Hospital, introduced at the scientific meeting of American Heart Association held in Dallas that a new anticoagulant, Edoxban, developed by the Daiichi Sankyo Co., Ltd., was more effective in preventing blood clots and strokes than the widely used one in a large-scale later clinical trial, and the risk of bleeding was significantly lower than that of Favalin.

Items	Specifications
Appearance	White powder
Solubility	Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
Melting Point	>213°C (dec.)

Certificates

Basic Info

Product Name:

Edoxaban

Other Name:

Ethanediamide,N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-;Ethanediamide,N-(5-chloro-2-pyridinyl)-N′-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-;N1-(5-Chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide;Edoxaban;DU 176;N-(5-Chloropyridin-2-yl)-N′-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide;876652-15-2

CAS No.:

480449-70-5

Molecular Formula:

C24H30ClN7O4S

InChIKeys:

InChIKey=HGVDHZBSSITLCT-JLJPHGGASA-N

Molecular Weight:

548.065

Exact Mass:

548.06

EC Number:

1592732-453-0

UNII:

NDU3J18APO

DSSTox ID:

DTXSID50197398

NCI Thesaurus Code:

C96539

Color/Form:

White to pale yellowish-white crystalline powder

ATC Code:

B01|B01AF03|B - Blood and blood forming organs

HScode:

2934999090

Categories:

Blood System Drugs

Characteristics

PSA:

165

XLogP3:

1.4

Density:

1.4±0.1 g/cm3

Melting Point:

Crystals as monohydrate from ethanol + water. MP: 245-48 (decomposes) /Edoxaban tosylate/

Refractive Index:

1.646

Water Solubility:

In water, 93.29 mg/L at 25 °C (est)

Storage Conditions:

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20 °C. /Edoxaban tosylate/|Store at 20-25 °C (68-77 °F); excursions permitted to 15 deg - 30 °C (59 deg - 86 °F). /Edoxaban tosylate/

Vapor Pressure:

2.03X10-21 mm Hg at 25 °C (est)

PKA:

6.7None

Henrys Law Constant:

Henry's Law constant = 3.11X10-34 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa 6.7 /Edoxaban tosylate/

Experimental Properties:

The solublilty decreases with increasing pH. It is slightly soluble in water, pH 3 to 5 buffer, very slightly soluble at pH 6 to 7; practically insoluble at pH 8 to 9 /Edoxaban tosylate/|Hydroxyl radical reaction rate constant = 1.55X10-12 cu cm/molec-sec at 25 °C (est)

See More Edoxaban Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Edoxaban Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Avanafil,Tirzepatide,Semaglutide,Pregabalin,Nootropics,MT2

Location:
Room 1-2208, Lianhecaifu Square, No2177, Tianchen Road, Gaoxin District, Jinan City, Shandong Province, China

Payment Terms:
L/C,100% TT in advance

Average lead Time:
3

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
11-50

Year of Establishment:
2012

Certifications:
business license

Founded in 2012, Jinan Million Pharmaceutical Co., Ltd (Jinan Milin Pharmaceutical Co., Ltd) is a modern pharmaceutical enterprise guided by innovation. Million pharm has excellent research and development capabilities and complete industrial bases with international quality management system. It is dedicated to the research, development, production and customization of pharmaceuticals and advanced pharmaceutical intermediates.

Jinan Million Pharmaceutical Co., Ltd has been focusing on the research of Cerebro-cardiovascular drugs, Central nervous system drugs, Anti-cancer drugs, Antibacterial drugs and others for 12 years; the products are: Apixaban, Lurasidone, Bexagliflozin, Votioxitine, Loxo-292/Selpercatinib, Baricitinib and intermediates. Million has worked with reputable customers, like METROCHEM API PVT LTD; BDR LIFESCIENCES PVT.LTD; INCETPAT PHARM; SRINI CHEM; EVA PHARMA; PHARMAFFILIATES ANALYTICS & SYNTHETICS (P) LTD; ....from India, Egypt, Canada...

Jinan Million Pharmaceutical Co., Ltd has a 1,500㎡ R&D center in the Zhongguancun E Valley (Qihe) Incubator, equipped with complete test equipment, such as high-performance liquid chromatography, nuclear magnetic resonance spectrometer, liquid chromatography mass spectrometer, automatic polarimeter, etc., which can meet the needs of various laboratory scale tests in different conditions. The pilot workshop is equipped with 50L and 100L glass reactors, high and low temperature equipment, etc., which can support organic chemical reactions at -100°C or 200°C. In addition, Million has a production site in Linyi city with many independent production lines, such as: production line of Apixabn intermediate 20 tons/year, production line of Lurasidon intermediate 10 tons/year, which can meet the commercial production of various products.

The technical team is composed of high-level talents in major of pharmacy, bio-pharmaceutical or chemical synthesis, of which 10% has doctor’s degree and 15% has master’s degree. The team members are young and energetic with innovative spirit and willing to overcome obstacles.

Jinan Million Pharmaceutical Co., Ltd adheres to the business philosophy of "dedication and innovation", insists on pioneering and innovating, constantly improves the quality system, and vigorously trains technical and management talents to build an elite team and serves customers better. Looking forward to cooperate with you for joint development and common progress.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
China	Edoxaban TBSYLATE MONOHYDRATE 99% white powder	1 MT	Jul 4, 2023

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