Food grade high purity N-Ribosylnicotinamde (NR);Nicotinamide riboside

What is Nicotinamide riboside (NR)  ?

Nicotinamide ribose is naturally occurring in milk. Other milk-derived products such as whey and yeast-containing foods are also thought to be natural sources of nicotinamide ribose. The molecular structure of nicotinamide ribose is very similar to that of vitamin B. It was recently discovered by scientists to be a derivative of vitamin B3 that increases levels of nicotinamide adenine dinucleotide (NAD +) in the body.

Nicotinamide Riboside Chloride is a crystalline form of nicotinamide riboside (NR) chloride called NIAGEN, which is generally regarded as safe (GRAS) for use in foods and dietary supplements. Nicotinamide riboside is a source of vitamin B3 (niacin), which enhances oxidative metabolism and prevents metabolic abnormalities caused by high-fat diets. Nicotinamide riboside is a newly discovered NAD (NAD+) precursor vitamin.

USES: Nicotinamide riboside has been implicated in increasing tissue NAD concentrations and inducing insulin sensitivity as well as enhancing deacetylase (sirtuin) function. Its ability to increase NAD production suggests that nicotinamide riboside may also enhance mitochondrial health, stimulate mitochondrial function and induce the production of new mitochondria. Other Chemicalbook studies using nicotinamide riboside in Alzheimer's disease models have shown that the molecule is bioavailable to the brain and may provide neuroprotection by stimulating NAD synthesis in the brain. In addition, a 2012 study observed that mice consuming a high-fat diet supplemented with nicotinamide riboside gained 60% less weight compared to mice consuming the same high-fat diet without nicotinamide riboside. Nicotinamide riboside chloride (3-carbamoyl-1-[(2R,3R,4S5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-pyridin-1-ium chloride; also known as 1-(β-D-ribofuranosyl)nicotinamide chloride) is a known salt form of nicotinamide riboside, despite the presence of the useful properties of nicotinamide riboside and its chloride salts (e.g. in the context of pharmaceutical or nutritional supplements), they are often in need of refinement.

Nicotinamide Riboside Benefits

1. It’s Easily Converted Into NAD+ – Research shows that NAD+ levels continue to fall with age, but one way to raise these levels is to consume NAD+ precursors (the building blocks of DNA) such as nicotinamide riboside. Animal studies show that it raises blood NAD+ levels by up 2.7 times; further, it is more readily used by the human body than other NAD+ precursors
2. It Activates Enzymes That May Promote Healthy Aging – Nicotinamide riboside helps increase NAD+ levels in the body, and in response, NAD+ activates certain enzymes that may promote healthy aging. One group is sirtuins, which appear to improve lifespan and overall health in animals. Studies indicate that sirtuins may repair damaged DNA, boost stress resistance, reduce inflammation and offer other benefits that promote healthy aging 
3. It May Help Protect Brain Cells – Within brain cells, NAD+ helps control the production of PGC-1-alpha, a protein that appears to help protect cells against oxidative stress and impaired mitochondrial function