Pramipexole free base

(6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine;SND-919;(6S)-4,5,6,7-Tetrahydro-2-amino-6α-(propylamino)benzothiazole;(6S)-N'-Propyl-4,5,6,7-tetrahydrobenzothiaChemicalbookzole-2,6α-diamine;(S)-4,5,6,7-Tetrahydro-N'-propylbenzothiazole-2,6-diamine;(S)-6-(Propylamino)-4,5,6,7-tetrahydrobenzothiazole-2-amine;(S)-Pramipexole;Pramipexolefreebase

PramipexoleDihydrochloride: C10H17N3S?2HCl. [104632-25-9]. Crystallizes from methanol, melting point 296-298°C. [α]D20>-67.2°(C=1, methanol). Dopamine D2 receptor antagonist. Used to treat Parkinson's disease. Production method: Dissolve 0.02mol 2,6-diamino-4,5,6,7-tetrahydrobenzothiazole in 34ml DMF, add 0.022mol n-propionaldehyde, and heat at 50°C for 1 hour. Cool, add 0Chemicalbook.02mol sodium borohydride, and heat at 50°C for 30 minutes. Most of the solvent was evaporated under reduced pressure, and the residue was dissolved in 20 ml of water, and adjusted to Ph value 1 with 2 mol/L hydrochloric acid. The aqueous layer was extracted with ethyl acetate, and the extract and organic layer were discarded. Add potassium carbonate to the water layer to make it alkaline, and then extract with ethyl acetate. The extract is dried and concentrated, and an ether solution containing HCl is added to obtain pramipexole dihydrochloride with a yield of 42% and a melting point of 286-288°C. 4-propylaminocyclohexanone (I) is brominated with hydrobromic acid in acetic acid, the product (II) is condensed with thiourea, and then acidified to obtain pramipexole dihydrochloride.

PramipexoleDihydrochloride: C10H17N3S?2HCl. [Chemicalbook104632-25-9]. Crystallizes from methanol, melting point 296-298°C. [α]D20>-67.2°(C=1, methanol).