 Home > Biochemical Engineering > Amino Acids and Derivatives > Carbamylglutamic acid for Sale > China Professional Factory Manufacturer Supply High Qulity N-CARBAMYL-L-GLUTAMIC ACID/N-carbamylglutamate(NCG) CAS 1188-38-1

China Professional Factory Manufacturer Supply High Qulity N-CARBAMYL-L-GLUTAMIC ACID/N-carbamylglutamate(NCG) CAS 1188-38-1 buy - large image1

China Professional Factory Manufacturer Supply High Qulity N-CARBAMYL-L-GLUTAMIC ACID/N-carbamylglutamate(NCG) CAS 1188-38-1 buy - image1

China Professional Factory Manufacturer Supply High Qulity N-CARBAMYL-L-GLUTAMIC ACID/N-carbamylglutamate(NCG) CAS 1188-38-1 buy - image2

China Professional Factory Manufacturer Supply High Qulity N-CARBAMYL-L-GLUTAMIC ACID/N-carbamylglutamate(NCG) CAS 1188-38-1 buy - image3

China Professional Factory Manufacturer Supply High Qulity N-CARBAMYL-L-GLUTAMIC ACID/N-carbamylglutamate(NCG) CAS 1188-38-1 buy - image4

China Professional Factory Manufacturer Supply High Qulity N-CARBAMYL-L-GLUTAMIC ACID/N-carbamylglutamate(NCG) CAS 1188-38-1

Name: China Professional Factory Manufacturer Supply High Qulity N-CARBAMYL-L-GLUTAMIC ACID/N-carbamylglutamate(NCG) CAS 1188-38-1
Brand: Leader
SKU: pr23112940146
Price: 1 USD
Availability: InStock

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CAS No.:

1188-38-1

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

Leader

Packaging:

25KG/Drum

Price valid (until):

2023-12-29

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LEADER BIOCHEMICAL GROUP

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients

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Product Description
Seller Information
Inquiry History

Description

About Product Technical Details

CAS:	1188-38-1
MF:	C6H10N2O5
MW:	190.15
EINECS:	601-569-3
Product Categories:	CARBAGLU;A - H;Amino Acids;Modified Amino Acids
Mol File:	1188-38-1.mol

N-CARBAMYL-L-GLUTAMIC ACID Chemical Properties

Melting point	174°
Boiling point	438.1±45.0 °C(Predicted)
density	1.499±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
pka	3.71±0.10(Predicted)
form	Solid
color	White to Off-White

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37
WGK Germany	3
RTECS	LZ9870000
HS Code	2924190002

D-Glucosamine hydrochloride Chemical Properties

Melting point	190-194 °C (dec.)(lit.)
alpha	72.5 º (c=2, H2O, 5hrs.)
refractive index	72 ° (C=1, H2O)
storage temp.	2-8°C
solubility	H₂O: 0.1 g/mL, clear, colorless
form	crystalline
color	White
Water Solubility	soluble
Merck	14,4458
BRN	4157370
Stability:	Stable. Incompatible with strong oxidizing agents. Combustible.
InChI	InChI=1/C6H13NO5.ClH/c7-3-5(10)4(9)2(1-8)12-6(3)11;/h2-6,8-11H,1,7H2;1H/t2-,3-,4-,5-,6?;/s3
InChIKey	QKPLRMLTKYXDST-LPRXMDNASA-N
SMILES	[C@H]1(CO)OC([C@H](N)[C@@H](O)[C@@H]1O)O.Cl \|&1:0,5,7,9,r\|
LogP	-2.375 (est)
CAS DataBase Reference	66-84-2(CAS DataBase Reference)
EPA Substance Registry System	D-Glucose, 2-amino-2-deoxy-, hydrochloride (66-84-2)

Safety Information

Hazard Codes	F,Xi,Xn
Risk Statements	21-36/38-46-62-63
Safety Statements	24/25-53-36/37-26-25
WGK Germany	2
RTECS	LZ6665000
F	3-10
Hazard Note	Highly Flammable
TSCA	Yes
HS Code	29329985

Product Pictures

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About Our Group

Since 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture high quality raw materials and refined ingredients which is widely used at different industries areas like Pharm & chemicals industry, functional active ingredients industry, nutritional Ingredients industry, health care products industry, cosmetics industry, pharmaceutical and refined food, feed, oil industry, natural plant ingredients industries, agriculture industry etcs to provide top quality of GMP standards products.

All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, agriculture raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China.

Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research. Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates.

With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products. Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people.

We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.

We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

Our Factories Production Lines

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Our Factories R&D ability

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Our Factories warehouse 52000㎡

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Sales Team

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ECHEMI Editorial Reference

Carglumic acid, a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.
Solid
Carglumic acid is a urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia. It has a role as an orphan drug and a carbamylphosphate synthetase I activator. It is a N-acyl-L-glutamic acid and a member of ureas.|Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase. This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and cause neurologic problems, cerebral edema, coma, and death. Carglumic acid was approved by the U.S. Food and Drug Administration (FDA) on 18 March 2010.|Carglumic acid is a Carbamoyl Phosphate Synthetase 1 Activator. The mechanism of action of carglumic acid is as a Carbamoyl Phosphate Synthetase 1 Activator.|Carglumic acid is an orphan drug and a derivative of N-acetylglutamate that activates the first enzyme in the urea cycle that is responsible for removal and detoxification of ammonia, making this drug a valuable agent for therapy of hyperammonemia caused by rare forms of urea cycle defects. Clinical experience with carglumic acid is limited, but it has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury.|Carglumic Acid is an orally active, synthetic structural analogue of N-acetylglutamate (NAG) and carbamoyl phosphate synthetase 1 (CPS 1) activator, with ammonia lowering activity. NAG, which is formed by the hepatic enzyme N-acetylglutamate synthase (NAGS), is an essential allosteric activator of the enzyme carbamoyl phosphate synthetase 1 (CPS 1). CPS 1 plays an essential role in the urea cycle and converts ammonia into urea. Upon oral administration, carglumic acid can replace NAG in NAGS deficient patients and activates CPS 1, which prevents hyperammonaemia.

Certificates

Basic Info

Product Name:

Carbamylglutamic acid

Other Name:

L-Glutamic acid,N-(aminocarbonyl)-;Glutamic acid,N-carbamoyl-,L-;N-(Aminocarbonyl)-L-glutamic acid;Ureidoglutaric acid;N-Carbamoyl-S-glutamic acid;Carbamylglutamic acid;Carbamino-L-glutamic acid;N-Carbamyl-L-glutamic acid;N-Carbamoyl-L-glutamic acid;Carglumic acid;Carbaglu;OE 312;(S)-2-Ureidopentanedioic acid;(2S)-2-(Carbamoylamino)pentanedioic acid;Ucedane;52093-31-9

CAS No.:

1188-38-1

Molecular Formula:

C6H10N2O5

InChIKeys:

InChIKey=LCQLHJZYVOQKHU-VKHMYHEASA-N

Molecular Weight:

190.15

Exact Mass:

190.15

EC Number:

1308068-626-2

UNII:

5L0HB4V1EW

DSSTox ID:

DTXSID7046706

NCI Thesaurus Code:

C76884

ATC Code:

A16AA05|A - Alimentary tract and metabolism

Categories:

Amino Acids and Derivatives

Characteristics

PSA:

130

XLogP3:

-2.4

Appearance:

Solid

Density:

1.499g/cm3

Melting Point:

157-159 °C

Boiling Point:

438.1°C at 760 mmHg

Flash Point:

218.8ºC

Refractive Index:

1.544

Storage Conditions:

2-8°C

Vapor Pressure:

6.7E-09mmHg at 25°C

See More Carbamylglutamic acid Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Carbamylglutamic acid Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients

Location:
National Aerospace Economic & Technical Development Zone,Chang'an,Xi'an,China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
5

Total Annual Revenue:
$10 million-$25 million

Total Employees:
Above 1000

Year of Establishment:
2014

Certifications:
Level A of Tax Credit Registration Assessment by Government,Good Product Quality Management Certificate of Shanxi Province,China,Company Trade Union Qualification Certificate,Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina,AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China,FDA
24 Hours Team Service
Email
info@leader-biogroup.com
Hot Line
+86-029-68895030
+86-029-68569961
+86-029-68569962
Fax
+86-029-68895030

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories Base with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world.
- Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.
  
  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.
  
  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.
  
  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.
- Process Capability : It has more than 100 sets of multi-functional reaction reactors, such as 100l~6300l enamel, stainless steel, Hastelloy, etc. It can realize Grignard, coupling, bromination, Wittig reaction and other conventional reactions. There are microchannel reactor workshops, which can realize continuous production, energy conservation and emission reduction. It can realize high pressure, high vacuum rectification, ultra-low temperature (-80 ℃ ~-100 ℃), ultra-high temperature (300 ℃ ~400 ℃) and other special reactions. It can realize the customization and processing of customers' products.
Factory Overview

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Factory Warehouse

Factory Logistics Departments
GROUP HONOR
Honor Name: Level A of Tax Credit Registration Assessment
Issued By:National Administration of Taxation & Shaanxi Tax Bureau
Authorised Date:2018-09-16
Description: National Administration of Taxation & Shaanxi Tax Bureau

Honor Name: AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China
Issued By:China Association of Shaanxi product Quality management Center
Authorised Date:2018-12-31
Description:AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China

Honor Name:Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina
Issued By: China Association of Shaanxi product Quality management Center
Authorised Date:2018-12-31
Description: Excellent Group Enterprise of Quality and Integrity in Shaanxi Province,China

Honor Name: Products Patent Certificates

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Taiwan, China	NCG N-Carbamylglutamate N-CARBAMYL-L-GLUTAMIC ACID 96% white powder 1188-38-1	1 MT	Nov 24, 2023

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Email	info@leader-biogroup.com
Hot Line	+86-029-68895030
	+86-029-68569961
	+86-029-68569962
Fax	+86-029-68895030

China Professional Factory Manufacturer Supply High Qulity N-CARBAMYL-L-GLUTAMIC ACID/N-carbamylglutamate(NCG) CAS 1188-38-1

Product Description

Seller Information