High purity Macitentan CAS NO.441798-33-0
1 Inquiries
441798-33-0
Pharmaceutical Grade
99%
shanghai
Lonwin
1kg/bag,25kg/drum,25kg/bag
2024-02-02
CHEMICALS,REAGENTS
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceMacitentan is an orally active, non-peptide endothelin receptor antagonist for the treatment of idiopathic pulmonary fibrosis and pulmonary arterial hypertension.
Macitentan is a member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an endothelin receptor antagonist, an antihypertensive agent and an orphan drug. It is an organobromine compound, a member of pyrimidines, an aromatic ether, a ring assembly and a member of sulfamides. It derives from an ethylene glycol and an ACT-132577.|Macitentan was approved in October 2013. It is indicated for patients with pulmonary arterial hypertension, and is marketed under the brand name Opsumit. Macitentan is an antagonist/blocker of endothelin receptors on blood vessels and smooth muscle, and, thus, blocks the stimulation of vasculature hypertrophy, inflammation, fibrosis, proliferation, and vasoconstriction. Similar to all drugs acting on the renin-angiotensin system, macitentan is associated with embryo and fetal toxicity, so it should not be used in pregnancy and has special precautions that must be followed for all females of child-bearing age.|Macitentan is an Endothelin Receptor Antagonist. The mechanism of action of macitentan is as an Endothelin Receptor Antagonist.|Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). Macitentan has been associated with a low rate of serum enzyme elevations during therapy, but has yet to be implicated in cases of clinically apparent acute liver injury.|Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types.Basic Info-
Product Name:
Macitentan
Other Name:Sulfamide,N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N′-propyl-;N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N′-propylsulfamide;Macitentan;ACT 064992;Propylsulfamic acid N-[5-(4-bromophenyl)-6-[2-[(5-bromopyrimidin-2-yl)oxy]ethoxy]pyrimidin-4-yl]amide;Opsumit
CAS No.:441798-33-0
Molecular Formula:C19H20Br2N6O4S
InChIKeys:InChIKey=JGCMEBMXRHSZKX-UHFFFAOYSA-N
Molecular Weight:590.295
Exact Mass:588.27
EC Number:1308068-626-2
UNII:Z9K9Y9WMVL
DSSTox ID:DTXSID50196063
NCI Thesaurus Code:C87728
ATC Code:C02KX04|C - Cardiovascular system
Categories:
Characteristics-
PSA:
137
XLogP3:3.7
Density:1.675
Boiling Point:692.397°C at 760 mmHg
Flash Point:372.5±34.3 °C
Refractive Index:1.634
Water Solubility:Not water soluble
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
CHEMICALS,REAGENTS
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Location:
No 966 Huaxu Road, Qingpu District, Shanghai, 201702, P.R. China
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Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
10
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
11-50
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Year of Establishment:
2011
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
India
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500 G Oct 31, 2023 Post an enquiry for this product
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