Prazicuantel

Pls inputChinese name: Pyroquinone, Facebook and Whaapp+8618397614799，Chinese synonym: 2-cyclohexycarbonyl-1,3,4,6,7,11-hexahydro-2-pyrazine (2,1)- Α) Isoquinoline-4-one; Praziquantel; 7-11B Hexahydro-4H-pyrazine [2,1-a] isoquinolin-4-one; English name of Pineapple extract Praziquantel Synonyms 1-a] - isoquinolin-4-one, 2- (cycloxylcarbonyl) -1,2,3,6,7,11b-hexahydro-4H-pyrazine [2,1-a] arbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino (2,1-a) isoquinolin-4; 4h pyrazino (2,1-a) isoquinolin-4-one, 2- (cycloxylcarbonyl) -1,2,3,6,7,11b-hexah; 4H pyrazino - [2,1-a] - isoquinolin-4-one, 2- (cycloxylcarbonyl) -1,2,3,6,7,11b hexahydro -; Bilitricide; Droncit; Praziquantelforsystem suitability; 2- (Cyclohexanecarbonyl) -1, 3, 4, 6, 7, 11b hexahydro-4H pyrazino [2, 1- α] Isoquinolin-4-oneCAS number 55268-74-1, molecular formula C19H24N2O2, molecular weight 312.41, EINECS number 259-559-6, related class antibiotics; Pesticide residues, veterinary drugs, and fertilizers; For broad-spectrum anti fluke and tapeworm drugs; Veterinary medicine; Anti fluke and tapeworm; Veterinary drugs; Additive 1; Insecticides; Medical raw materials; Pharmaceutical raw materials; Raw materials; Small molecule inhibitors; Antiparasitic drugs; Medications; Insect repellent health supplements; Feed additives; Active pharmaceutical ingredients; Antibacterial and anti-inflammatory raw materials; Analyze standard products; Antiparasitic drugs; Other scientific research raw materials; Organic chlorine insecticides; Antifluke drugs; Insecticides; Medical raw materials; Standard products; Medical raw materials; Medical and veterinary drugs; Intermediate; Animal medicine raw materials; API active pharmaceutical ingredients; Chemical raw materials - active pharmaceutical ingredients; Animal medicine raw materials; Agricultural and veterinary raw materials; Pharmaceutical, pesticide, and dye intermediates; Additives; Pharmaceutical; API; CosmeticIngredients&Chemicals; API's; AChemicalbookromatics; Heterocycles; Intermediates&FineChemicals; Pharmaceuticals; BILTRICIDE; Antiparasitic; Chinese medicine reference substance; Organic chemistry; Animal medicine raw materials; Chemical raw materials; Organic intermediates; Animal raw materials; Intermediate of raw materials; Anti parasitic; Chemicals; Disinfection and sterilization; API raw materials - deworming; Facebook and Whatapp +8618397614799, Threema:F785WMTH，55268-74-1; Chemical reagents; API active pharmaceutical ingredients; Chemical raw materials; Industrialized Mol file 55268-74-1. Mol structural formula: Pyroquinone, melting point 136-138C, boiling point 1377 ℃, density 1.1209 (roughestimate), refractive index 1.5600 (estimate), flash point>110 ° (230 ° F), storage conditions: Sealedindry, Storeinfilter, under-20 ° C, solubility in ethanol is 5mg/mL, acidity coefficient (pKa) -0.98 ± 0.20 (Predicted) The form of powder or crystal color is obtained by crystallization from ethyl acetate/hexane, and the water solubility of the crystal is Freelysolubleinethanoolordichloromethane Slightly soluble in water Merck137802BRN761557BCSClass2EPA chemical information Praziquantel (55268-74-1). Praziquantel is a broad-spectrum insecticidal synthetic drug discovered abroad in the 1970s. It was reported to be effective against schistosomiasis in 1977 and was tested domestically in the same year. It has been proven to have significant therapeutic effects on schistosomiasis in Japan. This product is a colorless crystalline powder, odorless and slightly bitter, and is stable under normal conditions. Soluble in organic solvents such as chloroform and dimethyl sulfoxide, slightly soluble in ethanol, but insoluble in water. The histological observation results of in vivo and in vitro experiments showed that after the treatment of the drug, the glycogen of the schistosome body was significantly reduced, and ribonucleic acid and alkaline phosphatase were also reduced, while the activity of alkaline protein reaction or acid phosphatase increased. The mechanism of action is that praziquantel has a significant killing effect on adult schistosomiasis. Its insecticidal mechanism, at the molecular level, is that praziquantel rapidly disrupts the Ca2+balance in the worm's body. On the one hand, it leads to excitation of worm activity and muscle contraction, making the parasitic schistosome in the portal vein system unable to adhere to the blood vessel wall and be carried into the liver by blood flow (liver migration), resulting in damage; The second is to cause damage to the syncytial cortex of Schistosoma, which not only affects the absorption, excretion, and secretion functions of the worm, leading to disturbances in sugar metabolism, enzyme systems, etc., but also exposes the antigenic determinants on the worm's surface, allowing the host's immune system to recognize and attract a large number of inflammatory cells such as neutrophils, eosinophils, macrophages, etc. to aggregate around the worm and attack it....