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906673-24-3 | ChemExpress

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CAS No.:

906673-24-3

Port:

shanghai

Packaging:

10 kg

Price valid (until):

2024-04-01

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ChemExpress

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

CRO

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Product Description
Seller Information
Inquiry History

Description

Crisaborole

API of Crisaborole for the treatment of Mild to moderate atopic dermatitis
We can provide high-quality Crisaborole and its derived impurities.

Brand：ChemExpress
CAS：906673-24-3
Catalog_No：HY-10978
Molecular Formular:C14H10BNO3
Molecular Weight:251.05

Contact:
TEL：+1-970-439-2030 (USA)、+86 (21) 5895-0125 (Global)
Email：info@chemexpress.com

Brand Introduction:
ChemExpress focuses on providing small molecule and new modalities CDMO services for both pharmaceutical and biotech clients. Our comprehensive CRO & CDMO platform is engaged in the research and development, manufacturing and supply of regulatory starting materials, novel building blocks, intermediates, reference compounds, APIs and drug products. We are a one-stop service platform to support our client’s projects from early drug discovery, process development to commercialization.

ChemExpress Services:

Drug Discovery: synthetic chemistry; medicine chemistry; FTE/FFS services.

Process Development: APIs and intermediates development; formulation development.

New Modalities Development: ADC; peptide; oligonucleotide and so on.

Manufactory: support production from milligrams to kilograms, both with GMP and non-GMP capabilities.

Analytical Development & Quality Control: R&D testing; stability study; genotoxic impurity research and so on.

Regulatory CMC Support

Eany development services in Synthetic Chemistny:Providing serices related to high qualty compound synthesis,chemical custom synthesis and analytical chemistry.

Pharmaceutical Chemistry eaniy development services: including high-throughput screening, drug synthesis, seding compounds, lead compounds, and IND fling support.

Process development: Covers AP! & intermediates process development, validation, transfer, and formulation development.

Commerial producion:it hasa research and development base forthe producion otapis intermediates and prenarations and provdes commeria prouction semices.

CMC services: Provide one-stop CMC services, from lND to NDA stage of pharmaceutical research and development and dedlaration services, accelerate IND declaration.

ADC drug and highly active drug development and production: Provides a one-stop CRO & CDMO service for the small molecule aspect of ADC drugs, as well as customized ADC conjugation services.

Oligonucleotide drug process development and production: Provide oligonucleotide customized products and services to meet different needs.

Analytical testing services and quality control: Provide integrated analytical testing services and drug quality research support

ChemExpress committed to being a steadfast companion for our clients, gaining profound insight into their needs. Our focus is on accelerating the empowerment of global partners across the full spectrum, from preclinical stages to commercial production. This commitment aims for more streamlined drug development, swifter market entry, and an earlier positive impact on human health.

Product details：https://www.chemexpress.com/product/HY-10978

ECHEMI Editorial Reference

Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC50 of 0.49 μM.
Crisaborole is a member of the class of benzoxaboroles that is 5-hydroxy-1,3-dihydro-2,1-benzoxaborole in which the phenolic hydrogen has been replaced by a 4-cyanophenyl group. A phosphodiesterase 4 inhibitor that is used for treatment of mild to moderate atopic dermatitis in children and adults. It has a role as a phosphodiesterase IV inhibitor, an antipsoriatic and a non-steroidal anti-inflammatory drug. It is a benzoxaborole, an aromatic ether and a nitrile.|Crisaborole is a novel oxaborole approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis. This non-steroidal agent is efficacious in improving disease severity, reducing the risk of infection and reducing the signs and symptoms in patients 2 years old and older. It reduces the local inflammation in the skin and prevents further exacerbation of the disease with a good safety profile. Its structure contains a boron atom, which facilitates skin penetration and binding to the bimetal center of the phosphodiesterase 4 enzyme. It is currently under development as topical treatment of psoriasis.|Crisaborole is a Phosphodiesterase 4 Inhibitor. The mechanism of action of crisaborole is as a Phosphodiesterase 4 Inhibitor.

Basic Info

Product Name:

Crisaborole

Other Name:

Benzonitrile,4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-;4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile;AN 2728;Crisaborole;4-[(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile;Eucrisa;Staquis;1187189-21-4;1073669-75-6

CAS No.:

906673-24-3

Molecular Formula:

C14H10BNO3

InChIKeys:

InChIKey=USZAGAREISWJDP-UHFFFAOYSA-N

Molecular Weight:

251

Exact Mass:

251.05

UNII:

Q2R47HGR7P

DSSTox ID:

DTXSID10238231

ATC Code:

D11AH06|D - Dermatologicals

HScode:

2926909090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

62.5

XLogP3:

1.56828

Density:

1.3±0.1 g/cm3

Flash Point:

211.4±31.5 °C

Refractive Index:

1.629

Water Solubility:

H2O: Insoluble

See More Crisaborole Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Crisaborole Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
CRO

Location:
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

Payment Terms:
TT against copy of documents

Average lead Time:
3

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
Above 1000

Year of Establishment:
2006

Company Profile
Founded in 2006, ChemExpress focuses on providing small molecule and new modalities CDMO services for both pharmaceutical and biotech clients. Our comprehensive CRO & CDMO platform is engaged in the research and development, manufacturing and supply of regulatory starting materials, novel building blocks, intermediates, reference compounds, APIs and drug products. We are a one-stop service platform to support our client’s projects from early drug discovery, process development to commercialization.

Over the past 17 years, we have established a state-of-the-art QC/QA system aligning with ICH guidelines for pharmaceutical manufacturing. We provide our clients with high-quality products and CMC services across the entire life-cycle of drug development.

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Crisaborole	1 G	Feb 21, 2026
India	Crisaborole	7 G	Feb 3, 2024
India	Crisaborole	5 G	Jan 2, 2024
India	Crisaborole	5 G	Dec 31, 2023

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