1174018-99-5 | ChemExpress
1 Inquiries
1174018-99-5
shanghai
10 kg
2024-04-01
CRO
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceRelebactam (formerly known as MK-7655) is a novel,intravenous,class A and class C B-lactamase inhibitor and is currently under evaluation in combination with imipenem/cilastatin for the treatment of resistant Gram-negative infections.In vitro studies demonstrated that relebactam restored imipenem's activity against KPC-producing Enterobacteriacae，lowering imipenem MICs from 16-64 to 0.12-1mg/L at a concentration of 4 mg/L. Moreover, relebactam is able to lower imipenem MICs for P. aeruginosa，particularly in strains with depressed OprD expression and increased AmpC expression.Conversely, the addition of relebactam to imipenem does not seem to provide any adjunctive benefit against A.baumanii or S.maltophilia or against MBL-producing Enterobacteriacae.A non-inferiority, Phase 3 trial evaluating the efficacy and safety of imipenem/relebactam compared to piperacillin/tazobactam for the treatment of HAP and VAP(ClinicalTrials.gov Identifier: NCT02493764) is currently recruiting. A Phase 3 study evaluating the efficacy and safety of imipenem/relebactam (200/100-500/250 mg depending on renal function) compared to colistimethate sodium plus imipenem/cilastatin for the treatment of imipenem-resistant bacterial infections,including HAP, VAP, cIAIs and cUTIs, has recently been completed and results are pending(ClinicalTrials.gov Identifier: NCTO2452047).In Phase 2 trials, imipenem/relebactam was well tolerated, with diarrhea, nausea, vomiting and headache being the most commonly reported adverse events.Basic Info
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Product Name:
Relebactam
Other Name:Sulfuric acid Mono-[7-oxo-2-(piperidin-4-ylcarbaMoyl)-1,6-diaza-bicyclo[3.2.1]oct-6-yl] ester;Sulfuric acid mono[(1R,2S,5R)-7-oxo-2-[(4-piperidinylamino)carbonyl]-1,6-diazabicyclo[3.2.1]oct-6-yl] ester;MK-7655(Relebactam);RELEBACTAM;(2S,5R)-sulfuric acid mono{[(4-aminopiperidin-4-yl)carbonyl]-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl}ester;(2S,5R)-7-oxo-2-(piperidin-1-ium-4-ylcarbamoyl)-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate;MK7655;Relebactam(MK-7655)
CAS No.:1174018-99-5
Molecular Formula:C12H20N4O6S
InChIKeys:SMOBCLHAZXOKDQ-ZJUUUORDSA-N
Molecular Weight:348.38
Exact Mass:348.38
Color/Form:Off-White to Light Yellow
Categories:
Characteristics-
Density:
1.59
Melting Point:>252°C (dec.)
PKA:-4.59±0.18(Predicted)
Critical Temperature & Pressure:Hygroscopic, -20°C Freezer, Under inert atmosphere
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Seller Information
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Business Type:
Manufactory
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Main Products:
CRO
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Location:
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
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Payment Terms:
TT against copy of documents
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Average lead Time:
3 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
Above 1000
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Year of Establishment:
2006
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
China
Relebactam
25 KG Mar 5, 2025 Post an enquiry for this product
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