EIDD-1931 & EIDD-2801
3258-02-4
Shanghai
1Kg/Aluminum foil bag
2024-05-15
Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate
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Product Description
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Seller Information
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DescriptionN4-Hydroxyctidine, or EIDD-1931, is a ribonucleoside analog which induces mutations in RNA virions. N4-hydroxycytidine was first described in the literature in 1980 as a potent mutagen of bacteria and phage. It has shown antiviral activity against Venezuelan equine encephalitis virus, and the human coronavirus HCoV-NL63 in vitro. N4-hydroxycytodine has been shown to inhibit SARS-CoV-2 as well as other human and bat coronaviruses in mice and human airway epithelial cells. It is orally bioavailable in mice and distributes into tissue before becoming the active 5’-triphosphate form, which is incorporated into the genome of new virions, resulting in the accumulation of inactivating mutations. In non-human primates, N4-hydroxycytidine was poorly orally bioavailable. A [remdesivir] resistant mutant mouse hepatitis virus has also been shown to have increased sensitivity to N4-hydroxycytidine. The prodrug of N4-hydroxycytidine, [EIDD-2801], is also being investigated for its broad spectrum activity against the coronavirus family of viruses.Basic Info
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Product Name:
N4-Hydroxycytidine
Other Name:Uridine,4-oxime;Cytidine,N-hydroxy-;N4-Hydroxycytidine;N-Hydroxycytidine;EIDD 1931;NHC;85373-26-8
CAS No.:3258-02-4
Molecular Formula:C9H13N3O6
InChIKeys:InChIKey=XCUAIINAJCDIPM-XVFCMESISA-N
Molecular Weight:259.218
Exact Mass:259.22
UNII:C3D11PV2O4
DSSTox ID:DTXSID20186274
Categories:
Characteristics-
PSA:
135
XLogP3:-2.2
Density:1.93±0.1 g/cm3(Predicted)
Melting Point:169-172 °C @ Solvent: Methanol
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate
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Location:
hisense intelligence valley,no 2116,of phoenix road
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Payment Terms:
TT against copy of documents,D/P,L/C
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Average lead Time:
7
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Total Annual Revenue:
Less than $1 million
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Total Employees:
11-50
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Year of Establishment:
2017
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
