High quility Sodium caprate 99% CAS NO (1002-62-6)

Chemical Structure: Sodium caprate, also known as sodium decanoate, is the sodium salt of capric acid, a medium-chain fatty acid with a 10-carbon chain. Its chemical formula is C10H19NaO2.

Physical Properties: Sodium caprate is typically found as a white to off-white powder or crystalline solid. It is soluble in water and forms clear solutions. It has a molecular weight of approximately 216.25 g/mol.

Synthesis Method: Sodium caprate can be synthesized through the neutralization reaction between capric acid and sodium hydroxide, resulting in the formation of the sodium salt along with water as a byproduct.

Pharmaceutical Applications: Sodium caprate is widely used as an absorption enhancer in pharmaceutical formulations, particularly in oral drug delivery systems. It helps improve the absorption of poorly permeable drugs across biological membranes, such as the intestinal epithelium.

Mechanism of Action: Sodium caprate acts by transiently disrupting the integrity of the tight junctions between epithelial cells, thereby increasing paracellular permeability and facilitating the passage of drugs and other molecules across the epithelial barrier.

Enhancement of Drug Bioavailability: By enhancing drug absorption, sodium caprate can improve the bioavailability and efficacy of orally administered drugs, potentially reducing the required dosage and enhancing therapeutic outcomes.

Safety and Toxicity: Sodium caprate is generally regarded as safe (GRAS) for use in pharmaceutical formulations when used within specified concentrations and under appropriate regulatory guidelines. However, excessive use or exposure may cause gastrointestinal irritation.

Regulatory Status: Sodium caprate is approved for use as an excipient in pharmaceutical formulations by regulatory agencies such as the FDA (U.S. Food and Drug Administration) and the European Medicines Agency (EMA).

Formulation Considerations: Sodium caprate is often incorporated into oral dosage forms such as tablets, capsules, and solutions. It may be used alone or in combination with other absorption enhancers or excipients to achieve optimal drug delivery and absorption profiles.

Research and Development: Ongoing research focuses on further elucidating the mechanisms of action of sodium caprate, optimizing its use in pharmaceutical formulations, and exploring its potential applications in novel drug delivery systems for improved therapeutic outcomes.