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1,2-Dipalmitoyl-sn-glycero-3-PG (sodium salt)

Name: 1,2-Dipalmitoyl-sn-glycero-3-PG (sodium salt)
Brand: HDC CHEM
SKU: pr2406031252
Price: 33 USD
Availability: InStock

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CAS No.:

200880-41-7

Grade:

Pharmaceutical Grade

Content:

98%

Port:

Beijing or Shanghai

Brand:

HDC CHEM

Packaging:

1g/Bottle, 3g/Bottle, 5g/Bottle, 10g/Bottle, 20g/Bottle, 30g/Bottle, 50g/Bottle

Price valid (until):

2024-08-31

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DALIAN HANDOM CHEMICALS CO.,LTD.

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

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Product Description
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Description

Product Details

Product Name: 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt)

Abbreviation: DPPG-Na

Synonyms: DPPG, Na; DPPG L-5116; 1,2-Dipalmitoyl-sn-glycero-3-PG (sodium salt); 1,2-Dipalmitoyl-sn-glycero-3-phosphorylglycerol sodium salt; 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATIDYL-RAC-GLYCEROL, NA SALT; 1,2-Dipalmitoyl-sn-glycero-3-phosphorylglycerol sodium salt (DPPG)

CAS No.: 200880-41-7

Molecular Formula: C73H143Na2O16P

Brief Introduction:

1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) is suitable for the preparation of anionic liposomes, which is a common choice of negatively charged membrane materials and plays a key role in improving the stability of liposomes. It has been widely used in the development of liposome drugs and the prescription of marketed products. It is also used in some liposome projects in the clinical stage, such as cisplatin liposomes Lipoplatin.

Solubility:

1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) can dissolve in water to form salts that can combine with cations (such as Na+).

Surface Active Properties:

1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) has surface active properties in aqueous solution and can form micelle structures.

Preparation Method:

1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) can be prepared by reacting palmitic acid with glycerol. The specific preparation method is often to first react palmitic acid with a base (such as sodium hydroxide) to form sodium palmitate, and then react with glycerol to form it.

Test Items		Specifications
Appearance		This product should be white to off-white powder
Identification	Infrared Spectroscopy	The infrared absorption spectrum of this product should be consistent with that of the reference substance
Identification	Thin-Layer Chromatography	The position and color of the main spots displayed by the test solution should be the same as those of the reference solution.
Related Substances	Impurity A	Not more than 0.5%
	Impurity B	Not more than 0.5%
	Impurity C	Not more than 0.5%
	Other individual impurities	Not more than 0.5%
	The total amount of other impurities	Not more than 1.0%
Free fatty acids		Not more than 0.3%
Purity of palmitic acid		Not less than 98.0%
Water		Not more than 2.0%
Heavy Metals		Not more than 10ppm
Arsenic (As)		Not more than 0.0002%
Calcium (Ca)		Not more than 0.0250%
Sodium (Na)		Should be between 3.1% and 3.3% (Calculated on the anhydrous basis)
Phosphorus (P)		Should be between 4.1% and 4.3% (Calculated on the anhydrous basis)
Residual Solvents	Acetone	Not more than 0.5%
	Methanol	Not more than 0.3%
	Tetrahydrofuran(THF)	Not more than 0.072%
	Chloroform	Not more than 0.006%
	n-Hexane	Not more than 0.029%
	Acetic Acid	Not more than 0.5%
Bacterial endotoxin		The amount of bacterial endotoxin per 1 mg should be less than 0.3EU
Microbial Limits	The total number of aerobic bacteria	Not more than 1000CFU/g
	The total number of moulds and yeasts	Not more than 100CFU/g
	Escherichia coli	Negative/g
Content		Calculated on the anhydrous basis, the content of C38H74NaO10P shall not be less than 98.0%

Applications:

Synthetic phospholipid DPPG-Na is a PG-based synthetic phospholipid, commonly used as liposome membrane material and emulsifier. Specific application examples include cytarabine multivesicular liposomes(Depocyt), morphine sulfate multivesicular liposomes(DepoDur), bupivacaine multivesicular liposomes(Exparel), etc.

Packaging:

1g/bottle, 3g/bottle, 5g/bottle, 10g/bottle, 20g/bottle, 30g/bottle, 50g/bottle or according to the specific requirements from customers.

Recommended Storage Conditions:

Short-term storage at room temperature; more than three months is best stored at 2-8 degrees Celsius; more than one year is best stored at -20±5 degrees Celsius. For reducing the absorption of the moisture, it should be slowly warmed to ambient temperature before opened.

Shelf Life:

24 months if stored under above conditions.

Basic Info

Product Name:

1,1′-[(1R)-1-[[[(2,3-Dihydroxypropoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] dihexadecanoate sodium salt (1:1)

CAS No.:

200880-41-7

Molecular Formula:

C38H75O10P.Na

InChIKeys:

InChIKey=ZDTRCZFSIBOLMV-ODZMYOIVSA-N

Categories:

Research

Class:

Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator

Status:

Research compound — Not FDA approved

Mechanism:

A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.

EC50 (HGF Binding KD):

65 pM

Activity note:

Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).

Source:

Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.

Clinical Development:

NCT04488419

References

PubChem:

PubChem

UNII:

9WYX65A5C2

Literature:

Benoist CC, et al. J Pharmacol Exp Ther. 2014 — HGF/c-Met mechanism; McCoy AT, et al. Neurobiol Learn Mem. 2014 — Synaptogenesis data (Retracted 2025); Athira Pharma: Fosgonimeton (prodrug) pipeline status

Disclaimer:

Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Seller Information

Business Type:
Manufactory

Main Products:
Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

Location:
RM702, Building 21, Liuhe Road, Ganjingzi Dist, Dalian, Liaoning, China

Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15

Total Annual Revenue:
$5 million-$10 million

Total Employees:
51-100

Year of Establishment:
2020

Dalian Handom Chemicals Co., Ltd.(HDC CHEM) is a professional 15-Year-Experienced Supplier of APIs & Intermediates, Pharmaceutical Excipients, Food & Nutraceutical Ingredients, Personal Care Chemicals and Specialty Chemicals from northeast of China, which strives to provide customers with high-quality products and comprehensive service across all over the world, our main products cover Retatrutide Lyophilized Powder, Retatrutide, Tirzepatide, Tirzepatide Lyophilized Powder, Semaglutide, Mazdutide, Cagrilintide, LL-37, Thymosin Alpha 1(Thymosin α1), MT-2, MOTS-c, HEP-1, TB-500, NAD+, GHK-Cu, Glow, Klow, Selank, Semax, Glutathione, 5-Amino-1MQ, ARA-290, SS-31, DSIP, SNAP-8, Medetomidine, Medetomidine Hydrochloride, Salcaprozate Sodium, Sodium 8-(2-hydroxybenzamido)octanoate, 2,6-Dimethyl Beta Cyclodextrin, mPEG-DMG-2K, mPEG-DSPE-2K, 1,2-Distearoyl-sn-3-phosphacholine(DSPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE), Pharmaceutical Grade Fructose, Lactose Anhydrous, Lactose Monohydrate, Orotic acid anhydrous, Orotic acid monohydrate, 6-Methyluracil, Chitosan, Mushroom Chitosan, Chitosan Hydrochloride, Chitosan Oligosaccharide, Alginate Oligosaccharide, Inulin, L-Serine, Mung Bean Peptide, Walnut Peptide, Rice Peptide, Oyster Peptide, Sea Cucumber Peptide, Hydrolyzed Keratin, Folic Acid, Vitamin E Acetate, Vitamin B2, Riboflavin Sodium Phosphate, Pyridoxal 5'-phosphate Monohydrate, Vegan Vitamin D3, Vitamin A Palmitate, Vitamin A Acetate, Apple Pectin, Citrus Pectin, Sunflower Pectin, Salidroside, Urolithin A, Milk Thistle Extract, Saffron Extract, Red Clover Extract, Sulforaphane, Glucoraphanin, Soy Isoflavones, Soy Lecithin, Soya Lecithin, Egg Yolk Lecithin, Phosphatidylserine, Cooling Agent WS-3, Cooling Agent WS-5, Cooling Agent WS-10, Cooling Agent WS-12, Cooling Agent WS-23, Cooling Agent WS-27, Menthyl Lactate, Menthyl PCA, Avobenzone, Benzophenone-3 (UV-9), Benzophenone-4 (UV-284), Bis-ethylhexyloxyphenol Methoxyphenyl Triazine (Bemotrizinol), Diethylaminohydroxybenzoyl Hexyl Benzoate (UVA Plus), Diethylhexyl Butamido Triazone (Iscotrizinol), Disodium Phenyl Dibenzimidazole Tetrasulfonate (DPDT), Ethylhexyl Triazone (UVT-150), Homosalate, Octocrylene, 2-Ethylhexyl Salicylate (Octyl Salicylate), 2-Ethylhexyl Trans-4-Methoxycinnamate (OMC), 2-Phenylbenzimidazole-5-Sulfonic Acid (UV-T), Lanolin Anhydrous, Palmitoyl Tripeptide-5, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Biotinoyl Tripeptide-1, etc.
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1,2-Dipalmitoyl-sn-glycero-3-PG (sodium salt)

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