Dexrazoxane cas 24584-09-6
24584-09-6
Analytical Reagent
99%
qingdao
AIRUIKE
1kg
Yes
2024-07-17
api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceDexrazoxane(ICRF187) is a cardioprotective agent.Target: OthersDexrazoxane is a cardioprotective agent. Dexrazoxane is a derivative of EDTA, dexrazoxane chelates iron and thus reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. The exact chelation mechanism is unknown, but it has be postulated that dexrazoxane can be converted into ring-opened form intracellularly and interfere with iron-mediated free radical gen
Solid
(+)-dexrazoxane is a razoxane. It has a role as a chelator, an antineoplastic agent, a cardiovascular drug and an immunosuppressive agent.|Dexrazoxane is a Cytoprotective Agent.|Dexrazoxane is a bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition.|The (+)-enantiomorph of razoxane.Basic Info-
Product Name:
Dexrazoxane
Other Name:2,6-Piperazinedione,4,4′-[(1S)-1-methyl-1,2-ethanediyl]bis-;2,6-Piperazinedione,4,4′-propylenedi-,(+)-;2,6-Piperazinedione,4,4′-(1-methyl-1,2-ethanediyl)bis-,(S)-;4,4′-[(1S)-1-Methyl-1,2-ethanediyl]bis[2,6-piperazinedione];(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane;ICRF 187;NSC 169780;(S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane;Dexrazoxane;ADR 529;(S)-4,4′-(Propane-1,2-diyl)bis(piperazine-2,6-dione)
CAS No.:24584-09-6
Molecular Formula:C11H16N4O4
InChIKeys:InChIKey=BMKDZUISNHGIBY-ZETCQYMHSA-N
Molecular Weight:268.27
Exact Mass:268.27
UNII:048L81261F
NSC Number:169780
DSSTox ID:DTXSID3040647
NCI Thesaurus Code:C1333
Color/Form:Crystals from aqueous methanol/ether|Whitish crystalline powder
ATC Code:V03AF02|V - Various
HScode:2933599090
Categories:
Characteristics-
PSA:
98.8
XLogP3:-1.4
Appearance:white to off-white
Density:1.3±0.1 g/cm3
Melting Point:193 °C
Boiling Point:531.5°C at 760 mmHg
Flash Point:275.3±30.1 °C
Refractive Index:1.540
Water Solubility:H2O: Sparingly soluble ;DMSO: >20mg/mL
Storage Conditions:Desiccate at RT
Vapor Pressure:2.0X10-15 mm Hg at 25 deg C /Estimated/
Specific rotation:D +11.35° (c = 5 in DMF)
PKA:2.1None
Henrys Law Constant:Henry's law constant = 2.1X10-19 atm-cu m/mole at 25 °C /Estimated/
Dissociation Constants:2.1|pKa = 2.1
Experimental Properties:Hydroxyl radical reaction rate constant = 2.0X10-10 cu cm/molec-sec at 25 °C /Estimated/
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals
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Location:
Huangdao District, Qingdao City, Shandong Province (formerly Room 606-2, Building 1, No. 10 Beijing Road, Jiaonan City)
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Payment Terms:
TT against copy of documents,D/P,D/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
15 days
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
51-100
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Year of Establishment:
2023
Company Certificates-
Credit rating certificate
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Hazardous Chemicals Business License
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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