Hot Sale CAS 11115-82-5 Enduracidin Hydrochloride / Enduracidin HCl
What is Enduracidin Hydrochloride / Enduracidin HCl ?
Enramycin is a peptide antibiotic produced by fermentation of Streptomyces fungicidicus, which combines unsaturated fatty acids with more than ten amino acids. The main components are enramycin A and B, which are used in their hydrochloride form. White or slightly yellowish white powder (the coarse product is a gray or grayish brown powder with a special odor). Decomposed at 234-238 ºC, easily soluble in dilute hydrochloric acid, slightly soluble in water, methanol, ethanol, and insoluble in acetone.
Enramycin has strong activity against Gram positive bacteria, especially against harmful Clostridium in the intestine. After long-term use, it is not easy to develop drug resistance because it changes the bacterial community in the intestine, so the utilization of nutrients in feed is good, which can promote weight gain and improve feed conversion rate in pigs and chickens.
| Items | Specifications |
| Product name | Enduracidin Hydrochloride / Enduracidin HCl |
| CAS No. | 11115-82-5 |
| MF | C106H135Cl2N26O31R |
| MW | 2340.2677 |
| EINECS.No | 695-076-0 |
| Melting Point | 238-245 °C (decomp) |
| Appearance | White Powder |
| Shelf Life | 2 Years When Properly Stored |
| Storage | Keep in a cool, dry, dark location in a tightly sealed container or cylinder. |
Specification
| Items | Standard | Results | Single conclusion |
| Characters | Should be gray or gray-brown powder;Special smell | Gray-brown powder | Conforms |
| Assay | Contain 99.0%~110.0% of the labeled amount of Enramycin | Enramycin:100.8% | Conforms |
| Identification | In the 250-256nm wavelength range with minimal absorption.In the269-275nm wavelength range of maximum absorption | The minimal absorbance is at the wavelength of 254nm;The maximum absorbance is at the wavelength of 272nm | Conforms |
| The color and location of main spots which is the test materials showed,should be the same as main spots of standard | The same as main spots of standard |
| Granularity | 100% pass 2# sieve | Conforms | Conforms |
| PH | Should be 5.0~8.0 | Conforms | Conforms |
| Loss on drying | ≤ 10.0% | 7.4%. | Conforms |
| Conclusion:Complies with Import veterinary drug quality standards |
| 2-chloro-3,5-Xylenol | 0.3% Max |
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| Clarity of solution | Clear solution free of particles |
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Function
Enramycin has a strong activity against Gram-positive bacteria, especially Clostridium in the intestine. After long-term use, it is not easy to develop drug resistance because it changes the bacterial population in the intestine. Therefore, the use of nutrients in feed is good, which can promote weight gain in pigs and chickens and increase feed conversion rates. Enramycin oral LD50 was 10g per kilogram of weight in large mice and 522.9 mg in 4 weeks of age. However, Enramycin(crude crystal) used for feed addition was oral, 11 g per kg of body weight in rats and mice and 8 g in broilers. Teratogenic and mutagenicity tests were negative. After oral administration, Enramycin only plays a role in the digestive tract and is not easily absorbed. After 6 to 12 H of administration of the chicken, enramycin excreted in the faeces reached 87.0 % to 100 %, and the residue of the piglets was very small. After 1 week of continuous use, the residue in the tissues was less than 25 μg / kg on the same day. Enramycin has no toxic effect on crops, fish and the environment after it is discharged by chickens and pigs. Therefore, it is a safe and effective animal specific antibiotic. Enramycin is preserved at 40 °C for 4 months, and the price is still above 90 %, but the price is reduced when the humidity is high. Enramycin is stored at room temperature for 12 weeks in the added feed, and the potency is not less than 90 %.
Application
1) Enramycin has a strong effect on Gram-positive bacteria. The main mechanism is to inhibit the synthesis of bacterial cell walls. The bacterial cell wall is mainly to maintain the appearance and maintain osmotic pressure stability. Its main component is viscous peptides. In Gram-positive bacteria, viscous peptides account for 65-95 % of the total cell wall. Enramycin can prevent the synthesis of sticky peptides, causing cell wall defects, causing intracellular osmotic pressure to increase, extracellular fluids to infiltrate the bacteria, causing bacteria to deform and swell, rupture and die. Enramycin mainly acts on the cracking stage of bacteria, not only sterilizing but also dissolving bacteria. The minimum antibacterial concentration is 0.05-3.13 μg / ml
2) The antibacterial ability of Enramycin to Clostridium aeruginosa is common in feeds. It can damage the small intestine, aggravate the severity of coccidiasis, and reduce the production performance of livestock and poultry. It is one of the main causes of chicken water stool, necrotizing enteritis and porcine diarrhea, and has become a universal concern in the world. It was found that Enramycin had the strongest antibacterial ability and no resistant strains were found in the test of Clostridium aeruginosa isolated from chicken farm by several progrowth antibiotics.
Company Information
Shaanxi TNJONE Pharmaceutical Technology Co., LTD., located in the beautiful ancient capital of Xi 'an, is committed to pharmaceutical raw materials, kill varieties, food and feed additives, chemical reagents, plant extracts and other fields, the enterprise adhering to provide customers with quality service, supply high-quality products. Our company after careful planning, hard study, gradually formed a complete service system, based on the domestic and foreign raw materials market special development. Make the raw materials industry bigger and stronger, and serve the vast number of new and old customers. With "world peace and health" as its responsibility, the company adheres to the service concept of "meeting all requirements of customers for products", and guarantees the service principle of "providing qualified products", so that you can get the "God-like" noble shopping enjoyment. Our company has more than 500 kinds of raw materials inventory at any time to meet the various needs of customers for products. The company's products all comply with the relevant national regulations, from the smallest packaging to tons of goods are available. Is your choice of raw materials the best partner.
Shaanxi TNJONE Pharmaceutical Technology Co., Ltd. is willing to rely on the rapid development of e-commerce and national policy support of the good environment background, nesting, welcome people from all walks of life to visit our company, exchange, and seek common development, looking forward to sharing with you, win-win, to realize the dream.
FAQ
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You can chat with us by Trademanager,WhatsApp or simply giving us an email, a phone call. All our contacts information can be found from our website.
2.Are you a manufacturer or trade company?
We are a professional manufacturer.
3.Can I get a sample?
Yes, free sample can be provided, but shipping cost is covered by your side.
4.What's your MOQ?
It is based on the different product. Some are 1g while some are 1 kg. Please be free to consult our salesman.
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6.Is there any discount?
Yes, some products are applied for discount, but it depends on the quantity.
7.Can you do OEM for me?
Yes,we accept OEM orders, just contact us and give us your requirement. We will offer you a reasonable price and make samples ASAP.
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