Quality Lonidamine Food Grade

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Product Name:    Lonidamine
Synonyms:    af1890;lonidamin;1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid;1H-Indazole-3-carboxylicacid, 1-[(2,4-dichlorophenyl)Methyl]-;1-(2,4-dichlorbenzyl)-indazole-3-carboxylicacid;1-(2,4-dichlorobenzyl)-1h-indazole-3-carboxylicaci;Lonidamine (AF1890);Lonidamine, 99%, mitochondrial hexokinase inhibitor
CAS:    50264-69-2
MF:    C15H10Cl2N2O2
MW:    321.16
EINECS:    256-510-0
Product Categories:    API;DORIDAMINA;inhibitor;Anti-cancer&immunity
Mol File:    50264-69-2.mol


Lonidamine is a derivative of indazole-3-carboxylic acid. It is a kind of orally administrated small molecule, which can inhibit the glycolysis process through inactivating the hexokinase (the first step in glycolysis). It has been shown that cancer cell primarily generates energy through glycolysis process. Therefore, Lonidamine has been used for the treatment of several kinds of cancers. One special property of Lonidamine is that it seems to enhance aerobic glycolysis in normal cells, but inhibit glycolysis only in cancer cells. In addition, there are also evidences that Lonidamine may increase the occurrence of apoptosis. It has also been shown that Lonidamine is effective in the treatment of benigh prostatic hyperplasia (BPH).

Lonidamine CAS 50264-69-2  of  Chemical Properties
Melting point     207-209°C
Boiling point     537.9±45.0 °C(Predicted)
density     1.4835 (rough estimate)
refractive index     1.6070 (estimate)
storage temp.     Sealed in dry,2-8°C
solubility     Soluble in DMSO (up to 25 mg/ml).
pka    3.00±0.10(Predicted)
form     solid
color     White
Stability:    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey    WDRYRZXSPDWGEB-UHFFFAOYSA-N
CAS DataBase Reference    50264-69-2(CAS DataBase Reference)