Hair Loss Treatment Ingredients Fevipiprant Qaw039 Powder CAS 872365-14-5
What is Fevipiprant /Qaw039 ?
Fevipiprant, also known as NVP-QAW039 or QAW039, is an oral active and potent CRTh2 receptor antagonist and potentially useful for asthma treatment. [(3)H]-QAW039 displayed high affinity for the human CRTh2 receptor (1.14 ± 0.44 nM) expressed in Chinese hamster ovary cells, the binding being reversible and competitive with the native agonist prostaglandin D2(PGD2). QAW039 was also a potent inhibitor of PGD2-induced cytokine release in human Th2 cells. Fevipiprant reduces eosinophilic airway inflammation and is well tolerated in patients with persistent moderate-to-severe asthma and raised sputum eosinophil counts despite inhaled corticosteroid treatment. Fevipiprant demonstrates a favorable safety profile.
Fevipiprant, a drug primarily used to treat asthma, has recently been explored for its potential use in hair care. There is evidence to suggest a link between hair loss and inflammation in the scalp, and fevipiprant's anti-inflammatory properties could provide benefits for those experiencing hair loss or thinning.
Studies have shown that fevipiprant can reduce levels of certain inflammatory molecules in the scalp which contribute to hair loss. This suggests that fevipiprant could potentially be used as a preventative treatment for hair loss, particularly in individuals with underlying inflammatory scalp conditions.
Furthermore, fevipiprant may also promote hair growth. A study conducted on mice showed that treatment with fevipiprant increased hair growth and thickness compared to a control group. While more research is needed to determine its effectiveness in humans, these preliminary findings suggest that fevipiprant could have a positive impact on hair growth.
| Items | Specifications |
| Product Name | Fevipiprant /Qaw039 |
| CAS No. | 872365-14-5 |
| Appearance | white powder |
| Assay | 98% |
| MF | C19H17F3N2O4S |
| MW | 426.41 |
| Melting Point | 637.6±55.0 °C(Predicted) |
| Density | 1.44±0.1 g/cm3(Predicted) |
Certification
Technical Date Sheet:
| Test Items | Test Standards | Test Results |
Description |
White or off-white crystalline powder |
White crystalline powder |
Identification |
Positive |
Positive |
Loss on drying | ≤0.5% | 0.15% |
Residue on ignition | ≤0.5% | 0.05% |
Heavy metals | ≤20ppm | 5ppm |
Organic volatile impurities | Accord with USP41 requirement |
Complies |
Total impurities | ≤1.5% | <1.5% |
Purity | 97.0%~103.0% | 99.45% |
| Conclusion: This batch of product complies with the standard of USP41. |
Application
Fevipiprant is the for the treatment of hair loss dwindled, perhaps due more to commercial potential and chemical stability reasons than efficacy as the later studies of Setipiprant have focused on different chemical forms of the combining it with various nanoparticles to enhance delivery.
Fevipiprant reduces eosinophilic airway inflammation and is well tolerated in patients with persistent moderate-to-severe asthma and raised sputum eosinophil counts despite inhaled corticosteroid treatment. Fevipiprant demonstrates a favorable safety profile.
Company Information
Shaanxi TNJONE Pharmaceutical Technology Co., LTD., located in the beautiful ancient capital of Xi 'an, is committed to pharmaceutical raw materials, kill varieties, food and feed additives, chemical reagents, plant extracts and other fields, the enterprise adhering to provide customers with quality service, supply high-quality products. Our company after careful planning, hard study, gradually formed a complete service system, based on the domestic and foreign raw materials market special development. Make the raw materials industry bigger and stronger, and serve the vast number of new and old customers. With "world peace and health" as its responsibility, the company adheres to the service concept of "meeting all requirements of customers for products", and guarantees the service principle of "providing qualified products", so that you can get the "God-like" noble shopping enjoyment. Our company has more than 500 kinds of raw materials inventory at any time to meet the various needs of customers for products. The company's products all comply with the relevant national regulations, from the smallest packaging to tons of goods are available. Is your choice of raw materials the best partner.
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