Ziprasidone CAS 146939-27-7 high quality can be supplied from stock
1 Inquiries
146939-27-7
Pharmaceutical Grade
99%
Million
25kg/Cardboard Drum
2024-09-13
Apixaban Repotrectinib/TPX-0005,Edoxaban,Lurasidone,Elacestrant,Bexagliflozin,Baricitinib
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceZiprasidone(CP88059) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.IC50 value:Target: 5-HT receptor; Dopamine receptorZiprasidone possesses an in vitro 5-HT2A/dopamine D2 receptor affinity ratio higher than any clinically available antipsychotic agent. In vivo, ziprasidone antagonizes 5-HT2A receptor-induced head twitch with 6-fold higher potency than for blockade of d-amphetamine-induced hyperactivity, a measure o
Solid
Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms. It has a role as a psychotropic drug, a histamine antagonist, a muscarinic antagonist, a serotonergic antagonist, a dopaminergic antagonist and an antipsychotic agent. It is a member of piperazines, an organochlorine compound, a member of indolones and a 1,2-benzisothiazole.|Disorders such as schizophrenia and bipolar disorder can significantly impair mood, cognition, and behavior. These mental illnesses can often be accompanied by comorbidities such as depression and substance abuse, and can significantly impact the quality of life of patients and caregivers. Luckily, several treatment options for psychotic disorders have been introduced to market since the realization of chlorpromazine's antipsychotic properties in 1952. Second generation antipsychotics (commonly referred to as atypical antipsychotics) include [clozapine], [quetiapine], [olanzapine], [aripiprazole] and [ziprasidone] among others, and are generally thought to be as efficacious as first generation antipsychotics but differ in their adverse effect profiles. First generation antipsychotics are associated with extrapyramidal adverse effects while atypical antipsychotics are linked to weight gain, impaired glucose tolerance and metabolic syndrome. Ziprasidone is used to treat schizophrenia and bipolar disorder. It can effectively reduce the rate and time of relapses in schizophrenia, and can be used to treat manic episodes in bipolar disorder although the mechanism of action is unknown. Although ziprasidone is classified as an atypical antipsychotic, it appears to have a lower incidence of metabolic adverse effects compared to other medications in the same class.|Ziprasidone is an Atypical Antipsychotic.|Ziprasidone is an atypical antipsychotic used in the treatment of schizophrenia and bipolar disorder. Use of ziprasidone has not been consistently associated with serum enzyme elevations and has yet to be linked to instances of clinically apparent acute liver injury.|Ziprasidone is a benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone also inhibits the synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors.Basic Info-
Product Name:
Ziprasidone
Other Name:2H-Indol-2-one,5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-;5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one;5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-2-indolinone;Ziprasidone;CP 88059;Geodon;5-[2-[4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one;Zeldox
CAS No.:146939-27-7
Molecular Formula:C21H21ClN4OS
InChIKeys:InChIKey=MVWVFYHBGMAFLY-UHFFFAOYSA-N
Molecular Weight:412.94
Exact Mass:412.94
EC Number:203-794-9
UNII:6UKA5VEJ6X
DSSTox ID:DTXSID4023753
NCI Thesaurus Code:C47788
ATC Code:N - Nervous system
HScode:29211980
Categories:
Characteristics-
PSA:
76.7
XLogP3:3.8
Appearance:Solid
Density:1.4±0.1 g/cm3
Melting Point:304 °C
Boiling Point:554.8±50.0 °C at 760 mmHg
Flash Point:-2 deg C (28 deg F) - closed cup
Refractive Index:1.681
Water Solubility:7.18e-03 g/L
Storage Conditions:Refrigerator
Vapor Pressure:1.02X10-13 mm Hg at 25 deg C (est)
Henrys Law Constant:Henry's Law constant = 6.43X10-19 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa1 = 2.03 (amine); pKa2 = 7.09 (amine); pKa3 = 14.89 (secondary amine) (est)
Collision Cross Section:192.6 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]
Experimental Properties:White to slightly pink powder. MW: 467.41. Also prepared as the hemihydrate, mp >300 °C /Ziprasidone hydrochloride monohydrate/|Hydroxyl radical reaction rate constant = 3.34X10-10 cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Specific target organ toxicity â repeated exposure, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H373 May cause damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response P319 Get medical help if you feel unwell.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Apixaban Repotrectinib/TPX-0005,Edoxaban,Lurasidone,Elacestrant,Bexagliflozin,Baricitinib
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Location:
Room1-2208,Lianhecaifu Square,No2177,Tianchen road,Gaoxin district
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Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
3
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
51-100
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Year of Establishment:
2012
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Certifications:
certification of high-tech enterprise
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
Taiwan, China
Ziprasidone
25 G Aug 23, 2024 Post an enquiry for this product
