N-N-DIETHLYSULFAMOYL CHLORIDE (DESC)

Insecticides such as diflubenzuron are specific and low toxicity insecticides belonging to the benzoyl class. They have stomach toxicity and contact killing effects on pests. They inhibit chitin synthesis in insects, prevent larvae from forming new skin during molting, and cause insect deformities and death. However, their efficacy is slow. This medicine has a specific effect on Lepidoptera pests. Safe to use, with no adverse effects on fish, bees, and natural enemies. The mode of action is gastric toxicity and contact killing, with no systemic absorption. Difenapyr is a benzoylurea based insect growth regulator. The mechanism of action is to inhibit the synthesis of chitin by pests, which is effective against various Lepidoptera pests. At an effective dosage, it has no harmful effects on plants and has no adverse effects on beneficial organisms such as birds, fish, shrimp, frogs, bees, ladybugs, step beetles, spiders, sand flies, red eye wasps, ants, parasitic wasps, etc. It has a slow efficacy against pests. The prevention and control targets have specific effects on Lepidoptera pests, and have good control effects on various pests such as Coleoptera and Diptera. There are no significant adverse effects on beneficial organisms, natural enemies, etc. It is mainly used on crops such as apples, pears, citrus, corn, rice, and cruciferous vegetables to prevent and control various pests such as apple leaf roller moth, beet armyworm, pear fruit moth, pear psyllid, corn, wheat armyworm, citrus psyllid, cabbage caterpillar, etc.Insecticides such as diflubenzuron are specific and low toxicity insecticides belonging to the benzoyl class. They have stomach toxicity and contact killing effects on pests. They inhibit chitin synthesis in insects, prevent larvae from forming new skin during molting, and cause insect deformities and death. However, their efficacy is slow. This medicine has a specific effect on Lepidoptera pests. Safe to use, with no adverse effects on fish, bees, and natural enemies. The mode of action is gastric toxicity and contact killing, with no systemic absorption. Difenapyr is a benzoylurea based insect growth regulator. The mechanism of action is to inhibit the synthesis of chitin by pests, which is effective against various pests in the order Lepidoptera. At an effective dosage, it has no harmful effects on plants and has no adverse effects on beneficial organisms such as birds, fish, shrimp, frogs, bees, ladybugs, step beetles, spiders, sand flies, red eye wasps, ants, parasitic wasps, etc. It has slow efficacy against pests. The prevention and control targets have specific effects on Lepidoptera pests, and have good control effects on various pests such as Coleoptera and Diptera. There are no significant adverse effects on beneficial organisms, natural enemies, etc. It is mainly used on crops such as apples, pears, citrus, corn, rice, and cruciferous vegetables to prevent and control various pests such as apple leaf roller moth, beet armyworm, pear fruit moth, pear psyllid, corn, wheat armyworm, citrus psyllid, cabbage caterpillar, etc. Usage: To control citrus rust planthopper, 60-80 mg/kg spray was used from the peak egg incubation stage to the nymph stage. Tea geometrid: control tea geometrid by 100-200mg/kg spray from the peak incubation period to the third instar. Leaf miner: control citrus leaf miner 60-125mg.kg spray. Armyworm: effective ingredient 15~30g/hm ², spray water at the 3rd~4th instar of the first generation of armyworm, the 2nd generation of annual egg hatching peak, and the 3rd generation of armyworm at the 2nd~# instar. Ostrinia furnacalis: 100~200mg/L cardioplegia or spray is used during the initial incubation or peak spawning period. Rice leaf roller: 25 mg/L spray before 1-3 instars of larvae. Pieris rapae and Plutella xylostella: at the initial stage of larva occurrence, use 150~225g/hm ² or 25mg/L liquid medicine to spray. Spodoptera exigua and Spodoptera litura: spray with 100mg/kg solution at the initial stage of incubation. Cotton bollworm: spray with 3~4 mg/L solution during the peak spawning period. Citrus psyllid: spray with 100mg/L liquid medicine at nymph stage. Dendrolimus punctatus, Dendrolimus tentaculatus and Poplar Moth: at the young stage of larvae, spray water with 30~45g/hm ² of effective ingredients. This medicine has an egg killing effect on these pests. Mosquito larvae: effective ingredient 25-40g/hm ² sprayed on water surface area. Rope larvae: effective ingredient sprayed on the surface area of 0.5~1g/hm ². This medicine is effective against termites, ants, cockroaches, and storage pests. The toxic active ingredient has an acute oral LD50 of over 46401mg/kg in rats (there are also reports of over 1500mg/kg in rats). Rabbit acute transdermal LD50>2000mg/kg, acute inhalation LC50>30mg/L. Has a mild irritant effect on rabbit eyes and skin. The oral ineffective dose for rats is 125mg/kg per day. No animal teratogenic or mutagenic effects were observed within the experimental dose. Quails have an acute oral LD50>4640mg/kg, salmon has an LC50 of 0.3mg/L (30d), and bees have an LD50<30 μ g/individual. According to China's pesticide toxicity classification standards, diflubenzuron belongs to the category of low toxicity insecticides. Toxicity to aquatic organisms LC50 (96 hours, mg/L): 140 for rainbow trout, 135 for bluegill sunfish, harmless to bees LD50 (oral, dermal)>100 μ g/peak; Toxicity to natural enemies LC50 (8-day diet) Chemicalbook: North American quail and wild ducks have a diet of>4640mg/L, which is not harmful to carnivorous insects. The acute oral LD50 of the original drug in rats and mice is greater than 4640mg/L, the acute transdermal LD50 in rabbits is greater than 2g/kg, the acute transdermal LD50 in rats is 10g/kg, and the acute inhalation LC50 in rats is greater than 2.88mg/L. It is irritating to rabbit eyes but has no irritating effect on the skin. This medicine has no significant accumulation effect in animal bodies and can be quickly metabolized. Under experimental conditions, no mutagenic, teratogenic, or carcinogenic effects were observed. Two years of feeding experiment with no effective dose of 40mg/L for rats and 50mg/L for mice. Feeding experiment LC500.3mg/L on salmon for 30 days. Low toxicity to bees, acute exposure LD50>100 μ g/head; Low toxicity to birds, 8-day feeding test, acute oral LD50>4640mg/L for wild ducks and quails; Water flea LC50 (48 hours) 7.1 μ g/L. The chemical properties of the pure product are white crystals, with a temperature range of 230-232 ℃. Relative density 1.56, vapor pressure 1.32 × 10-5Pa (50 ℃). Easily soluble in acetonitrile and dimethyl sulfoxide, soluble in ethyl acetate, ethanol, and dichloromethane, slightly soluble in ether, benzene, and petroleum ether, with a solubility of 6.5g/L in acetone and 0.1mg/L in water. It is relatively stable to light and heat, stable to storage at room temperature, easy to decompose when exposed to alkali or strong acid, and can be decomposed by soil microorganisms. Industrial products are white to light yellow crystals, with a temperature range of 210-230 ℃. Application: Benzoylurea insecticide. Inhibit the synthesis of insect shell polysaccharides. Mainly has stomach toxicity and also has contact killing effect. The residual effect period is relatively long, but the speed of drug efficacy is slow. Used for controlling various pests of Lepidoptera, especially for larvae, and safe for crops and natural enemies. For example, to control diamondback moth, Spodoptera litura, Spodoptera exigua, Pieris rapae, etc., during the peak period of egg hatching to the peak period of the 1st to 2nd instar larvae, use 25% suspension 500~1000 times of liquid spray. To control the corn borer and corn iron beetle, in the early hatching period or peak egg laying period, 20% suspension agent can be used to irrigate the heart leaves or spray with 1000~2000 times of solution to kill eggs and newly hatched larvae. To control the slime worm, use 20% suspending agent 75-150g/hm2 and 750kg water to spray during the larval peak period. To control citrus leaf miner, 25% suspension was applied to spray with 2000 times liquid at the early stage of shoot pulling and the peak period of egg hatching. In addition, it can also prevent and control pear fruit moth, poison moth, pine caterpillar, rice leaf roller, etc. Application: Used to kill sticky insects on corn and wheat. It is particularly effective against Lepidoptera pests and also effective against various Coleoptera and Diptera pests. Fusarium oxysporum is a new insecticide that has a stomach toxic effect on the larvae of many important pests. It interferes with epidermal deposition, preventing insects from molting or metamorphosing properly and leading to death. It can also inhibit the formation of epidermis during the embryonic development of insect eggs, preventing the eggs from developing and hatching normally, and also have a certain inhibitory effect on the reproductive ability of insects. This product has a wide spectrum of insecticides, especially effective against Lepidoptera larvae. Due to its unique mechanism of action, it has low toxicity to humans and animals, and low harm to natural enemies, making it a relatively good selective insecticide developed in recent years. The production method involves heating and refluxing 2,6-difluorobenzamide and 4-chlorophenyl isocyanate in xylene, followed by cooling after the reaction is complete. The resulting crystals are washed with xylene and dried to obtain fipronil. The preparation method of 2,6-difluorobenzamide starts from 2,6-dichlorobenzonitrile and is obtained through fluorination and nucleophilic addition reaction. Refer to the preparation method of fluorouracil. The synthesis of insecticide urea