Triple Hormone Receptor Agonist GLP-1 Purity 99% 15mg Retatrutide CAS:2381089-83-2

• Retatrutide (LY3437943) acetate is a triple agonist peptide for the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R).

  Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively. It exhibits activity on mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191, and 0.794 nM, respectively.

  In vivo, Retatrutide (LY3437943) acetate engages with GCGR and enhances glucose tolerance in an ipGTT by acting through GIP or GLP-1 receptors. Activation via the glucagon receptor by Retatrutide acetate leads to significant weight reduction and increased energy expenditure. Retatrutide acetate can be utilized in research related to obesity.

  Retatrutide (LY-3437943) is an experimental drug for obesity developed by American pharmaceutical company Eli Lilly and Company. It is a triple hormone receptor agonist of GLP-1, GIP, and GCGR receptors. It has been shown to achieve a more than 24% mean weight reduction in adults without diabetes but with obesity or preobesity (overweight) during a phase 2 trial.The drug is a peptide with amino acid sequence YA1QGTFTSDYSIL2LDKK4AQA1AFIEYLLEGGPSSGAPPPS3.

  Retatrutide, LY3437943

  CAS#: 2381089-83-2

  Molecular Formula: C221H342N46O68

  Molecular Weight: 4731.33

  Sequence: H-Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-α-Me-Leu-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

  Appearance: White Powder

  Purity (HPLC): ≥99.0%

  Single Impurity (HPLC): ≤1.0%

  Sodium Content (HPLC): 5.0%-12.0%

  Moisture Content (Karl Fischer): ≤10.0%

  Peptide Content: ≥80.0%

  Storage: Store at 2-8 degrees Celsius in a dry and cool place.

  Packaging: 1g-1kg, plastic bottle

  Intended Use: For scientific research purposes

  Retatrutide, LY3437943

  CAS#: 2381089-83-2

  Molecular Formula: C221H342N46O68

  Molecular Weight: 4731.33

  Sequence: H-Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-α-Me-Leu-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

  Appearance: White Powder

  Purity (HPLC): ≥99.0%

  Single Impurity (HPLC): ≤1.0%

  Sodium Content (HPLC): 5.0%-12.0%

  Moisture Content (Karl Fischer): ≤10.0%

  Peptide Content: ≥80.0%

  Storage: Store at 2-8 degrees Celsius in a dry and cool place.

  Packaging: 1g-1kg, plastic bottle

  Intended Use: For scientific research purposes

Appearance: Powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

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