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Retatrutide (LY-3437943) is mainly used for weight loss and the treatment of type 2 diabetes.
(1) Mechanism of action: Retalglutide is a triple hormone receptor agonist that acts on glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent insulinotropic peptide receptor (GIPR) and Glucagon receptor (GCGR) achieves its therapeutic effect by activating all three receptors simultaneously.
(2) Clinical effect: When it comes to weight loss, retarglutide performed well in clinical trials. For example, in overweight and pre-sugar adults, its application resulted in weight loss of more than 17.5%, and some research results show that the maximum weight loss effect can reach 24.2%.
In the treatment of type 2 diabetes, retarglutide also shows significant blood sugar-lowering effects and helps control glycated hemoglobin (HbA1c) levels.
| Product Name | Retatrutide |
| CAS NO. | 2381089-83-2 |
| Other name | LY3437943 GIPR/GLP-1R |
| Appearance | White freeze dry Powder |
| Purity | 99.8%min. HPLC |
| Application | Drug peptides |
| Shelf Life | 24Months |
| Storage | Store at a temperature of 2-8 oC, protected from light |
(1) Triple agonist: Retalglutide is a receptor for glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide receptor (GIP) and glucagon receptor (GCG). A triple agonist, this unique multi-target mechanism of action enables it to demonstrate significant effects in weight loss and diabetes treatment.
(2) Significant weight loss effect: In clinical trials, retarglutide has shown excellent weight loss effect. Some research results show that the weight loss of subjects can reach up to 24.2%, which is almost equivalent to the effect of bariatric surgery.
(3) Improve blood sugar control: In addition to weight loss, retarglutide can also effectively control blood sugar levels and reduce glycated hemoglobin, making it suitable for the treatment of patients with type 2 diabetes.
10/12/15mg/vial,10vial/box
How is Retatrutide different from Semaglutide and Trizepatide ?
Mechanism:
1. Semaglutide work as (GLP-1) hormone agonist.
2. Tirezepatide work as (GLP-1 & GIP ) hormone agonist.
3. Retatrutide work as (GLP-1 & GIP & Glucagon) hormones agonist.
Weight loss in trials:
1. Semaglutide led to a 6-12% reduction in body weight in 28 weeks
2. Tirezepatide led to a 15-20% reduction in body weight in 72 weeks
3. Retatrutide led to a 25% reduction in body weight in 48 weeks
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