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Home > Pharmaceutical Intermediates > Immunological Agents > GS-441524 for Sale > High Quality 99% Intermediate GS-441524 CAS 1191237-69-0 Fast Shipping Manufacturer
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High Quality 99% Intermediate GS-441524 CAS 1191237-69-0 Fast Shipping Manufacturer

TDS 53 Inquiries

Unit Price: Get Latest Price
CAS No.:

1191237-69-0

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/Tin

Price valid (until):

2024-10-26

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
10 days
Qualification:
Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    Name

    GS-441524

    CAS number

    1191237-69-0

    Synonym

    GS-441524; GS 441524; GS441524; Remdesivir-metabolite, GS-5734-metabolite; GS5734-metabolite;

    Related CAS #

    1191237-69-0 (free base)   2378280-82-9 (HCl)   2378280-83-0 (sulfate)   1191237-69-0 (solution) 

    Description

    GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM.. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. GS-441524 was non-toxic in feline cells at concentrations as high as 100 uM and effectively inhibited FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low as 1 uM. Note: GS-441524 is an active metabolite of Remdesivir.

    Structure

        Shop High Quality 99% Intermediate GS-441524 CAS 1191237-69-0 Fast Shipping Manufacturer-Detailed Image 1

    Molecular Formula

    C12H13N5O4

    Molecular Weight

    291.1 g/mol

    Appearance

    Solid powder

    Quality Standard

    99%

    Shipping Condition

    Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

    Storage Condition

    Dry, dark and at 2~8 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

    Shelf Life

    >2 years if stored properly

    Sample package

    Aluminium foil bag, Bottle

    Commercial package

    Aluminium Tin

    Origin

    China


    GS-441524 More Info

     

    GS-441524 is an antiviral compound that has garnered attention primarily for its potential use in treating viral infections, particularly those caused by coronaviruses and other RNA viruses. It is an analog of nucleoside, specifically designed to inhibit viral replication, making it a subject of interest in both veterinary and human medicine.

    Key Features and Benefits:

    Antiviral Activity:

    GS-441524 has shown efficacy against a variety of viral pathogens, with a significant focus on coronaviruses, including the one responsible for COVID-19. It works by targeting and disrupting the viral RNA polymerase enzyme, which is essential for the virus's replication process.

    Mechanism of Action:

    As a nucleoside analog, GS-441524 mimics the building blocks of RNA, leading to premature termination of viral RNA synthesis when incorporated into the viral genome. This effectively prevents the virus from producing new viral particles, thereby limiting the spread of the infection.

    Clinical Research:

    Studies have indicated promising results in the use of GS-441524 for treating infections in both animals and humans. It has been evaluated in clinical settings for its safety, tolerability, and effectiveness in managing viral diseases.

    Veterinary Use:

    GS-441524 has received considerable attention for its application in veterinary medicine, particularly for treating feline infectious peritonitis (FIP), a serious viral disease in cats. The compound has demonstrated significant efficacy in improving the health outcomes of affected felines.

    Administration:

    GS-441524 can be administered in various forms, including oral formulations or injections, depending on the specific context of treatment and the target species.

    Ongoing Research:

    Ongoing studies and trials are focused on expanding the understanding of GS-441524's effects, optimizing dosing regimens, and exploring its application against a broader range of viral infections. Research continues to evaluate its long-term efficacy and safety profile.

    Safety and Considerations:

    While GS-441524 has shown promise, it is important for potential users to consult with qualified healthcare professionals regarding its use, particularly in the context of viral infections. As research progresses, guidelines on its use and clinical applications will continue to evolve.

    In summary, GS-441524 is an antiviral agent notable for its potential effectiveness against viral infections, particularly coronaviruses. Its unique mechanism of action and ongoing research make it a noteworthy compound in the field of infectious disease treatment, with applications in both human and veterinary medicine.



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    ECHEMI Editorial Reference
    GS-441524 is a nucleoside analogue that terminates the RNA chain of viral RNA-dependent RNA polymerase. GS-441524 was developed by Gilead Sciences, Inc as part of their research into human RNA virus disease such as Ebola. GS-441524 is a small molecule that exhibits potent antiviral activity against a number of RNA viruses, including the zoonotic severe acute respiratory syndrome (SARS) coronavirus ( Cho et al., 2012).
    GS-441524 is a C-nucleoside analog that is (2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile substituted by a 4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl group at position 2. It is the active metabolite of remdesivir and exhibits a broad range of inhibitory activity against various RNA viruses including HCV, parainfluenza and SARS-CoV. It has a role as a drug metabolite, an antiviral agent and an anticoronaviral agent. It is a pyrrolotriazine, a nitrile, a C-nucleoside and an aromatic amine.|GS-441524 is an adenosine nucleotide analog antiviral, similar to [remdesivir]. This molecule was patented in 2009. In vitro studies of GS-441524 have determined it has a higher EC50 than remdesivir against a number of viruses, meaning GS-441524 is less potent. GS-441524 continues to be studied in the treatment of Feline Infectious Peritonitis Virus, a coronavirus that only infects cats.

    Certificates

    Basic Info
    Product Name:

    GS-441524

    Other Name:

    (2R,3R,4S,5R)-2-(4-Aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furancarbonitrile;GS-441524;GS441524;(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile;GS-441524 solution;EVO984;EVO 984;EVO-984;GS 441524

    CAS No.:

    1191237-69-0

    Molecular Formula:

    C12H13N5O4

    InChIKeys:

    BRDWIEOJOWJCLU-LTGWCKQJSA-N

    Molecular Weight:

    291.26

    Exact Mass:

    291.096754

    UNII:

    1BQK176DT6

    Categories:

    Immunological Agents

    Characteristics
    PSA:

    150

    XLogP3:

    -1.27552

    Density:

    1.84±0.1 g/cm3(Predicted)

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

    Location:

    Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    10 days

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    11-50

    Year of Establishment:

    2013

    Company Certificates
    • Hangzhou Hyper Chemicals LimitedCertification Report by Bureau Veritas Certification Report by Bureau Veritas
    About HyperChem

    Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

    Our Competitiveness

    One-stop supply

    Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

    Among all the pharmaceuticals,

    90% of them with GMP certificates,

    85% of them with DMF files and

    50% of them passed FDA approval,

    30% get CEP certificate

    20% are new R&D products.

    Custom Repackaging Service


    We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

    Quality Control/Quality Assurance


    HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

    All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

    Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

    Professional

    Transparent Communication

    Fast Reaction,

    Professional Suggestion

    Beyond Expectation.

    We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

  • Inquiry History
    53 Inquiries
    Country Product Purchase Quantity Date Posted
    Turkey

    GS441524 powder CAS 1191237-69-0 Remdesivir GS-5734 Alprostadil pge

    1 PCS Jan 6, 2026
    Bulgaria

    Lowest price in the whole network 1191237-69-0 GS-441524

    100 BOU Nov 8, 2023
    United States

    GS441524 CAS 1191237-69-0 Cat Fip GS441 liquid 20mg 30mg 6ml 8ml 10ml

    4 MT Oct 18, 2023
    China

    GS 441524

    1 KG Dec 5, 2023
    Chile

    GS-441524

    100 MT Oct 5, 2026
    United States

    GS 441524

    30 MG Aug 3, 2026
    United States

    GS-441524

    100 MT Jul 9, 2026
    Poland

    GS441524 powder

    200 G Mar 11, 2026
    United States

    gs441524

    100  Feb 10, 2026
    South Korea

    GS-441524 20mg tablets

    3 PCS Feb 5, 2026
    Canada

    Alprostadil

    10 PCS Nov 25, 2025
    Portugal

    GS-441524

    10 G Nov 17, 2025
    Germany

    Gs 441524 99.9% purity white powder

    20 G Mar 30, 2025
    Portugal

    GS-441524

    16 MG Jan 8, 2025
    Pakistan

    GS-441524

    10 G Sep 13, 2024
    United States

    Gs441524

    100 MT Apr 3, 2024
    Turkey

    GS-441524

    100 G Feb 16, 2024
    Pakistan

    GS-441524

    21 MT Feb 11, 2024
    United States

    gs441524

    250 L Dec 28, 2023
    United States

    GS 441524

    10 L Dec 21, 2023
    Post an enquiry for this product
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