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Upadacitinib hemihydrate API

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CAS No.:

2050057-56-0

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

Shanghai

Brand:

HyperChem

Packaging:

1kg/Bag, 1kg/Tin, 5kg/Tin

Price valid (until):

2024-10-29

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Upadacitinib hemihydrate
CAS number	2050057-56-0
Synonym	ABT-494, ABT 494, ABT494, Upadacitinib
Related CAS	1310726-60-3 (free base) 1607431-21-9 (tartarte)
Description	Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.
Structure
Molecular Formula	C₁₇H₁₉F₃N₆O • 1/2H₂O
Molecular Weight	389.37 g/mol
Appearance	White solid powder
Quality Standard	Enterprise standard
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 2~8 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag, Bottle
Commercial package	Aluminium Tin
Origin	China

Upadacitinib More Info

Upadacitinib is a Janus kinase (JAK) inhibitor used to treat various inflammatory conditions. It is primarily indicated for:

Rheumatoid Arthritis : For adults with moderate to severe active rheumatoid arthritis who have not responded adequately to other disease-modifying antirheumatic drugs (DMARDs).
Psoriatic Arthritis : Effective for adults with active psoriatic arthritis.
Atopic Dermatitis : Approved for moderate to severe cases in patients aged 12 and older who have not responded to other treatments.
Ulcerative Colitis : Used in adults with moderately to severely active ulcerative colitis who have not responded to anti-TNF therapies.
Crohn's Disease : Indicated for adults with moderately to severely active Crohn's disease, particularly those who have had inadequate responses to TNF blockers.
Ankylosing Spondylitis and Axial Spondyloarthritis : For adults who are intolerant or unresponsive to TNF inhibitors.
Polyarticular Juvenile Idiopathic Arthritis : Approved for children aged 2 years and older who have not responded well to other medications.

Mechanism of Action

Upadacitinib works by selectively inhibiting the JAK1 enzyme, which plays a crucial role in the inflammatory process. By blocking this enzyme, it helps reduce inflammation and alleviate symptoms associated with the aforementioned conditions.

Administration and Dosage

Upadacitinib is available as an extended-release tablet and a liquid solution. The typical regimen involves taking the medication once daily for the tablet form or twice daily for the liquid solution. It should be taken consistently at the same time each day.

Side Effects

Common side effects include:

Upper respiratory tract infections
Nausea
Cough
Fever
Shingles
Increased risk of serious infections (e.g., tuberculosis)
Potential cardiovascular issues (e.g., heart attack or stroke) .

Approval History

Upadacitinib received approval from the FDA in 2019 for various indications, with subsequent approvals for additional uses in 2022 and 2023, reflecting its expanding role in treating chronic inflammatory diseases.In summary, Upadacitinib is a versatile treatment option for several autoimmune and inflammatory conditions, offering relief to patients who have not found success with other therapies.

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Certificates

Basic Info

Product Name:

Upadacitinib hemihydrate

Other Name:

Upadacitinib hemihydrate;UNII-NEW4DV02U5;NEW4DV02U5;2050057-56-0;Rinvoq (TN);Upadacitinib hydrate (JAN);D11048;(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide hydrate(2:1);1-Pyrrolidinecarboxamide, 3-ethyl-4-(3H-imidazo(1,2-a)pyrrolo(2,3-E)pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-, hydrate (2:1), (3S,4R)-;1831899-73-0

CAS No.:

2050057-56-0

Molecular Formula:

C34H40F6N12O3

InChIKeys:

GJMQTRCDSIQEFK-SCDRJROZSA-N

Exact Mass:

778.32505216

UNII:

NEW4DV02U5

Categories:

Antineoplastic Agents

Characteristics

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	UPADACITINIB HEMIHYDRATE	225 G	May 6, 2026
South Korea	Upadacitinib Hemihydrate	100 G	Mar 27, 2025

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