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Afoxolaner, Trade name: NexGard.

Name: Afoxolaner, Trade name: NexGard.
Brand: HyperChem
SKU: pr2410161073
Price: 2300 USD
Availability: InStock

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CAS No.:

1093861-60-9

Grade:

Veterinary grade

Content:

99.5%

Port:

HANGZHOU

Brand:

HyperChem

Packaging:

1/Bag/Ctn

Price valid (until):

2024-11-16

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Afoxolaner
CAS number	1093861-60-9
Synonym	Afoxolaner, Trade name: NexGard.
Description	Afoxolaner is a potent isoxazoline insecticide/acaricide, against Ixodes scapularis in dogs. A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30.
Molecular Formula	C₂₆H₁₇ClF₉N₃O₃
Molecular Weight	625.876
Appearance	Type white powder
Quality Standard	In-House
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life	>2 years if stored properly
Commercial package	Fiber Ctns
Origin	China

Afoxolaner Reference

1: Rehbein S, Fourie JJ, de Vos C, Anderson A, Larsen DL, Jeannin P. Efficacy of oral afoxolaner plus milbemycin oxime chewables against induced infestations with Dermacentor reticulatus in dogs. Parasitol Res. 2016 Jan 27. [Epub ahead of print] PubMed PMID: 26815036.

2: Snyder DE, Rumschlag AJ, Young LM, Ryan WG. Speed of flea knockdown of spinosad compared to afoxolaner, and of spinosad through 28 days post-treatment in controlled laboratory studies. Parasit Vectors. 2015 Nov 9;8:578. doi: 10.1186/s13071-015-1195-5. PubMed PMID: 26552479; PubMed Central PMCID: PMC4640350.

3: Ohmes CM, Hostetler J, Davis WL, Settje T, Everett WR. Comparative Efficacy of an Imidacloprid/Flumethrin Collar (Seresto®) and an Oral Afoxolaner Chewable (NexGard®) against Tick (Dermacentor variabilis and Amblyomma americanum) Infestations on Dogs: a Randomised Controlled Trial. Parasitol Res. 2015 Aug;114 Suppl 1:S81-94. doi: 10.1007/s00436-015-4515-y. PubMed PMID: 26152410.

4: Emmerich IU. [New drugs for small animals in 2014]. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2015;43(3):170-80. doi: 10.15654/TPK-150260. Epub 2015 May 27. German. PubMed PMID: 26013709.

5: Dryden MW, Smith V, Chwala M, Jones E, Crevoiserat L, McGrady JC, Foley KM, Patton PR, Hawkins A, Carithers D. Evaluation of afoxolaner chewables to control flea populations in naturally infested dogs in private residences in Tampa FL, USA. Parasit Vectors. 2015 May 24;8:286. doi: 10.1186/s13071-015-0897-z. PubMed PMID: 26003175; PubMed Central PMCID: PMC4445572.

6: Beugnet F, Liebenberg J, Halos L. Comparative efficacy of two oral treatments for dogs containing either afoxolaner or fluralaner against Rhipicephalus sanguineus sensu lato and Dermacentor reticulatus. Vet Parasitol. 2015 Apr 15;209(1-2):142-5. doi: 10.1016/j.vetpar.2015.02.002. Epub 2015 Feb 12. PubMed PMID: 25716658.Menthol crystals are widely used in:

ECHEMI Editorial Reference

Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family. Afoxolaner acts at ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes.
Afoxolaner is used to treat and control flea and tick infestations in dogs. After being ingested by a dog, afoxolaner is distributed throughout the dog’s body. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal.

Certificates

Basic Info

Product Name:

afoxolaner

Other Name:

Afoxolaner;1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-;afoxolaner-007;China biggest manufacturer,Afoxolaner,1093861-60-9;4-(5-(3-Chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-1-naphthamide;Avrana;Afulana;C10047600 Afoxolaner

CAS No.:

1093861-60-9

Molecular Formula:

C26H17ClF9N3O3

InChIKeys:

OXDDDHGGRFRLEE-UHFFFAOYSA-N

Molecular Weight:

625.87

Exact Mass:

625.87

EC Number:

200-001-8

DSSTox ID:

DTXSID50148921

Color/Form:

White to off-white

ATC Code:

QP53BE01|QP54AB51

Categories:

Veterinary Raw Materials

Characteristics

Density:

1.53±0.1 g/cm3(Predicted)

PKA:

12.45±0.46(Predicted)

Critical Temperature & Pressure:

Store at -20°C

See More afoxolaner Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H410 Very toxic to aquatic life with long lasting effects
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P273 Avoid release to the environment.
Response	P318 IF exposed or concerned, get medical advice. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More afoxolaner Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
Sri Lanka	Afoxolaner	1 MT	Apr 28, 2025
Denmark	Afoxolaner	100 KG	Sep 3, 2026
New Zealand	Afoxolaner	1 KG	May 21, 2024
Bangladesh	Butyl Acetate	1.00 KG	Nov 11, 2025

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