PH 797804 / 586379-66-0
586379-66-0
pharmaceutical Grade
99.9%
zhengzhou
Ouber
100g, 250g, 500g, 1kg, 5kg, 10kg, 20kg, 50kg, 100kg 1000kg
Yes
2027-01-01
OLED intermedaites,Pharmaceutical intermediates,Ligands and catalysts
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Product Details
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Seller Information
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DescriptionECHEMI Editorial ReferencePH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM; 4-fold more selective versus p38β and does not inhibit JNK2.IC50 value: 26 nM [1]Target: p38αMAPKin vitro: PH-797804 blocks LPS-induced TNF-α production and p38 kinase activity in the human monocytic U937 cell line, with comparable IC50 of 5.9 nM and 1.1 nM. PH-797804 has no inhibitory effect on either the JNK pathway (c-Jun phosphorylation) or ERK pathway (ERK phosphorylation) in U937 cells at concentrations up to 1 μ
PH 797804 is a member of the class of benzamides obtained by formal condensation of the carboxy group of 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1-yl}-4-methylbenzoic acid with the amino group of methylamine. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor and an anti-inflammatory agent. It is a member of benzamides, an organofluorine compound, a pyridone, an organobromine compound and an aromatic ether.|PH-797804 has been investigated for the treatment of Osteoarthritis.Basic Info-
Product Name:
PH797804
Other Name:Benzamide,3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethyl-;3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide;3-Bromo-4-[(2,4-difluorobenzyl)oxy]-1-[5-[(methylamino)carbonyl]-2-methylphenyl]-6-methylpyridin-2(1H)-one;PH 797804;1073667-47-6
CAS No.:586379-66-0
Molecular Formula:C22H19BrF2N2O3
InChIKeys:InChIKey=KCAJXIDMCNPGHZ-UHFFFAOYSA-N
Molecular Weight:477.2986664
Exact Mass:477.30
UNII:SI09I1V827|GEL7GRJ3R6
DSSTox ID:DTXSID70207342
HScode:2933399090
Categories:
Characteristics-
PSA:
58.6
XLogP3:3.24
Density:1.5±0.1 g/cm3
Boiling Point:593.2±50.0 °C at 760 mmHg
Flash Point:312.6±30.1 °C
Refractive Index:1.629
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
OLED intermedaites,Pharmaceutical intermediates,Ligands and catalysts
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Location:
No.1187 Kexuedadao, Shangjie District, Zhengzhou, China
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Payment Terms:
TT against copy of documents
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Average lead Time:
3 days
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2020
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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