Factory supply PNC-27 cas1159861-00-3 for wholesale Best Price

we sale full list with peptide products , any other requirements just contact me!

Name:Kim

email: sale3@xtlmh.com

WhatsApp: +86 17659922905

Description:

  PNC-27 is an anti-cancer peptide that mainly induces cancer cell membrane lysis by binding to HDM-2 protein, thereby killing cancer cells.PNC-27, an anticancer peptide, containing an HDM-2 binding domain corresponding to p53 residues 12-26 and a transmembrane penetrating domain, has been found to kill cancer cells but not normal cells by inducing membrane lysis. The 3D structure of the p53 residue of PNC-27 directly overlaps the structure of the same residue that binds HDM-2, suggesting that this peptide may target HDM-2 in the cell membrane. The researchers found significant levels of HDM-2 in the cell membranes of a variety of cancer cells but not in some untransformed cell lines. In colocalization experiments, PNC-27 bound to cell membrane-bound HDM-2. The researchers used a membrane localization signal to transfect a plasmid expressing full-length HDM-2 into PNC-27-insensitive untransformed MCF-10-2A cells and found that these cells expressed full-length HDM-2 on their cell surface. cells versus PNC-27. We concluded that PNC-27 targets HDM-2 in cancer cell membranes, allowing it to selectively induce membrane lysis in these cells.

  Our customers are all over the world, mainly selling in the United States, Canada, Australia, the United. Kingdom, the Ne  therlands, Germany, France and other EU countries, Southeast Asia, South America, and Oceania. We also have many customers.
 Our business is based on honesty and mutual trust. Sincerely look forward to establishing long-term mutually beneficial business relationships with customers around the world.



We supply large quantities of peptides.In addition to regular specifications, we can also customize according to customer requirements.
 The minimum order quantity is 1 box(10vials), we welcome customers to order samples for testing.Please contact us for COA or HPLC.
 We believe that as long as the quality is good enough will lead to long-term cooperation.Looking forward to your inquiry.

packaging and shipping

Suitable packaging:
The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken in consideration

Secure shipping:
Shipping by professional forwarder Security EMS/DHL/TNT /FedEx/UPS, Aus Post, Royal Mail express,etc. Door to door service.

Competitive prices:
A discount would be given when you make a large order. VIP price for next orders.

FAQ

  Q1:How to send order?
  A:Send order list to us,we quote best price for you,then ship package out and offer tracking nubmer to you after payment send.

  Q2:Do you have samples for our reference?
A:Sure,we can offer smaples,the customers will pay the freight.

  Q3:Any discount if order more?
A:Sure,the price is negotiable,you can get much better price if order big quantity.

 Q4:What about the delivery time?
A:Ship within 1-2 days after confirming payment (excluding Chinese holidays).5-10 working days to arrive your address.

 Q5:What kind of payment terms do you accept?
A:Payment can be made by Bank transfer, BTC,Credite Card,TT,Paypal,Alipay,Wechat,Visa,Mastercard,Appple Pay,Goolge Pay.

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