High Quality 99% Carbidopa CAS 28860-95-9 Powder Fast Shipping Good Price
TDS
28860-95-9
Pharmaceutical Grade
99.5%
Hangzhou
HyperChem
1kg/Bag
Yes
2025-01-05
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements
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Product Details
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Seller Information
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DescriptionECHEMI Editorial ReferenceCarbidopa is an inhibitor of DOPA decarboxylase, which is used in parkinson disease.Target: DOPA decarboxylaseCarbidopa (CD), a competitive inhibitor of aromatic l-amino acid decarboxylase that does not cross the blood-brain barrier, is routinely administered with levodopa (LD) to patients with Parkinson disease (PD) to reduce the peripheral decarboxylation of LD to dopamine [1]. CD premedication improves 11C-5-HTP PET image quality and facilitates detection of NET lesions. Because of th
Solid
Carbidopa (anhydrous) is 3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used (commonly as its hydrate) in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor, an antiparkinson drug and a dopaminergic agent. It is a member of hydrazines, a monocarboxylic acid and a member of catechols.|Carbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate. It potently inhibits aromatic amino acid decarboxylase (DDC) and due to its chemical properties, it does not cross the blood-brain barrier. Due to its activity, carbidopa is always administered concomitantly with [levodopa]. An individual formulation containing solely carbidopa was generated to treat nausea in patients where the combination therapy [levodopa]/carbidopa is not efficient reducing nausea. The first approved product by the FDA containing only carbidopa was developed by Amerigens Pharmaceuticals Ltd and approved on 2014. On the other hand, the combination treatment of carbidopa/levodopa was originally developed by Watson Labs but the historical information by the FDA brings back to the approval of this combination therapy developed by Mayne Pharma in 1992.|Levodopa (L-Dopa) is an amino acid precursor of dopamine and is the most effective and commonly used drug in the treatment of Parkinson disease. Levodopa is usually combined with carbidopa, which is an inhibitor of L-amino acid decarboxylase, the plasma enzyme that metabolizes levodopa peripherally. Treatment with the combination of levodopa and carbidopa has been associated with mild and transient increases in serum enzymes in a proportion of patients and with very rare instances of clinically apparent acute liver injury.|Carbidopa Anhydrous is the anhydrous, levorotatory isomer of a synthetic hydrazine derivative of the neurotransmitter dopamine. Carbidopa, a peripheral dopa decarboxylase inhibitor, is used as an adjunct with levodopa to prevent levodopa degradation to dopamine in extracerebral tissue, thereby decreasing the peripheral side effects of levodopa. Carbidopa does not penetrate the blood brain barrier; therefore, it does not interfere with the central nervous system (CNS) metabolism of levodopa to the active neurotransmitter dopamine which, in high concentrations in the brain, has anti-parkinsonian effects.|An inhibitor of DOPA DECARBOXYLASE that prevents conversion of LEVODOPA to dopamine. It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. It has no anti-parkinson activity by itself.CertificatesBasic Info-
Product Name:
Carbidopa
Other Name:Benzenepropanoic acid,α-hydrazinyl-3,4-dihydroxy-α-methyl-,(αS)-;Hydrocinnamic acid,α-hydrazino-3,4-dihydroxy-α-methyl-,L-;Benzenepropanoic acid,α-hydrazino-3,4-dihydroxy-α-methyl-,(S)-;Benzenepropanoic acid,α-hydrazino-3,4-dihydroxy-α-methyl-,(αS)-;(αS)-α-Hydrazinyl-3,4-dihydroxy-α-methylbenzenepropanoic acid;L-α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid;MK 486;L-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid;L-α-Methyl-α-hydrazino-β-(3,4-dihydroxyphenyl)propionic acid;L-α-Methyl-β-(3,4-dihydroxyphenyl)-α-hydrazinopropionic acid;L-α-Methyldopahydrazine;Carbidopa;(-)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate;L-α-(3,4-Dihydroxybenzyl)-α-hydrazinopropionic acid;1-α-(3,4-Dihydroxybenzyl)-α-hydrazinopropionic acid;(-)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinamic acid;α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid;α-Methyldopahydrazine;Hydrazino-α-methyldopa;L-α-Hydrazino-α-methyl-3,4-dihydroxyphenylpropionic acid;L-α-Methyl-α-hydrazino-3,4-dihydroxyphenylpropionic acid;N-Aminomethyldopa;L-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid;Lodosyn;HMD;Lodosin;(S)-Carbidopa;L-Carbidopa;(2S)-2-(Aminoazaniumyl)-3-(3,4-dihydroxyphenyl)-2-methylpropanoate;(2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid;Cabidopa;27925-91-3;31823-41-3
CAS No.:28860-95-9
Molecular Formula:C10H14N2O4
InChIKeys:InChIKey=TZFNLOMSOLWIDK-JTQLQIEISA-N
Molecular Weight:226.23
Exact Mass:226.23
EC Number:249-271-9
UNII:KR87B45RGH
NSC Number:751137
DSSTox ID:DTXSID4022735
NCI Thesaurus Code:C61803
ATC Code:N04BA03|N04BA02
HScode:2932999099
Categories:
Characteristics-
PSA:
116
XLogP3:-2.2
Appearance:Solid
Density:1.4±0.1 g/cm3
Melting Point:208 °C
Boiling Point:528.7±50.0°C at 760 mmHg
Flash Point:273.5±30.1 °C
Refractive Index:1.641
Water Solubility:3.8 mg/L
Storage Conditions:-20ºC
Vapor Pressure:5.27E-12mmHg at 25°C
PKA:2.3None
Dissociation Constants:2.3
Collision Cross Section:142.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H341 Suspected of causing genetic defects
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements
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Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
10 days
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
11-50
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Year of Establishment:
2013
Company Certificates-
![Hangzhou Hyper Chemicals LimitedCertification Report by Bureau Veritas]( "Certification Report by Bureau Veritas")
Certification Report by Bureau Veritas
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