High Quality Enalapril Maleate CAS 76095-16-4 Powder Fast Shipment Good Price

Enalapril Maleate More Info

Enalapril maleate is an angiotensin-converting enzyme (ACE) inhibitor used primarily for the treatment of hypertension (high blood pressure) and heart failure. It plays a significant role in the management of cardiovascular conditions by its ability to lower blood pressure and reduce the workload on the heart. Below is a detailed overview of this product:

Mechanism of Action

Enalapril is a prodrug that is converted to its active form, enalaprilat, after administration. Its mechanism of action involves the inhibition of the ACE enzyme, which is responsible for converting angiotensin I to angiotensin II, a potent vasoconstrictor. By limiting the production of angiotensin II, Enalapril causes the blood vessels to relax and widen (vasodilation), thus reducing blood pressure. Additionally, it decreases aldosterone secretion, leading to increased sodium and water excretion, further contributing to blood pressure reduction.

Indications

Enalapril is indicated for:

Hypertension:  It is used to lower blood pressure in adults and children aged 6 years and older.

Heart Failure:  Enalapril is employed in the management of symptomatic heart failure, improving symptoms and overall cardiac function.

Left Ventricular Dysfunction:  It is also indicated for the reduction of the risk of symptomatic heart failure and cardiovascular events in patients with left ventricular dysfunction following a myocardial infarction.

Dosing and Administration

Enalapril is administered orally, typically in the form of tablets. The common dosing regimen includes:

Hypertension:  The initial dose for adults is usually 5 mg once daily, which may be adjusted based on the patient's response, with a typical maintenance dose ranging from 10 to 40 mg per day.

Heart Failure:  The initial dose is often 2.5 mg to 5 mg once daily, and the maintenance dose may be titrated based on the clinical response.

Renal Function:  Dosage adjustments may be necessary in patients with renal impairment.

Side Effects

Common side effects associated with Enalapril include:

Cough:  A persistent dry cough is a common side effect in some patients due to elevated bradykinin levels.

Hyperkalemia:  Increased potassium levels in the blood may occur, requiring monitoring of serum potassium.

Hypotension:  Some individuals may experience low blood pressure, especially after the first dose.

Angioedema:  A rare but serious side effect involving swelling of the face, lips, or throat, which requires immediate medical attention.

Renal Impairment:  Changes in kidney function may occur; thus, renal function should be monitored regularly.

Contraindications and Precautions

Contraindications:  Enalapril is contraindicated in individuals with a known hypersensitivity to ACE inhibitors, a history of angioedema related to previous ACE inhibitor treatment, and in patients with bilateral renal artery stenosis.

Precautions:  Caution should be exercised in patients with a history of renal impairment, heart failure, or electrolyte imbalances. Regular monitoring of blood pressure and renal function is recommended, especially during initiation and dosage adjustments.

Conclusion

Enalapril maleate is a vital medication in the management of hypertension and heart failure, effective in lowering blood pressure and providing cardiovascular protection. Its action as an ACE inhibitor offers substantial benefits, but careful monitoring for side effects and contraindications is essential for safe and effective use. Patients are advised to work closely with healthcare providers to optimize their treatment regimen and manage any potential adverse effects.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

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Suitable for more than 50kg 
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For sample orders: 
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1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders:
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.