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API Nabumetone

Name: API Nabumetone
Brand: Hyper Chem
SKU: pr2412161467
Price: 50 USD
Availability: InStock

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CAS No.:

42924-53-8

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2025-01-16

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information

Description

Name	Nabumetone
CAS number	42924-53-8
Synonym	Nabumetone, Relafen, Relifex, Gambaran, Arthraxan, BRL 14777
Description	Nabumetone is a non-steroidal anti-inflammatory drug (NSAID), the only 1-naphthaleneacetic acid derivative. It is a nonacidic NSAID that is rapidly metabolized in the liver to a major active metabolite, 6-methoxy-2-naphthyl acetic acid. As found with previous NSAIDs, nabumetone's active metabolite inhibits the cyclooxygenase enzyme and preferentially blocks COX-2 activity (which is indirectly responsible for the production of inflammation and pain during arthritis). The active metabolite of nabumetone is felt to be the compound primarily responsible for therapeutic effect. Comparatively, the parent drug is a poor inhibitor of COX-2 byproducts, particularly prostaglandins. It may be less nephrotoxic than indomethacin.
Structure
Molecular Formula	C₁₅H₁₆O₂
Molecular Weight	228.286
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Nabumetone More Info

Nabumetone is a non - steroidal anti - inflammatory drug (NSAID).

1. Chemical and Pharmacological Properties

Chemical Structure: Nabumetone has a unique chemical structure that belongs to the class of arylalkanoic acid derivatives. Its chemical formula is .

Mechanism of Action: It works mainly by inhibiting the cyclo - oxygenase (COX) enzymes. COX enzymes are responsible for the production of prostaglandins, which play a key role in inflammation, pain, and fever. Nabumetone is a relatively selective inhibitor of COX - 2 (the inducible form of cyclo - oxygenase), compared to COX - 1 (the constitutive form). By reducing the production of prostaglandins, it helps to relieve pain, reduce inflammation, and lower fever.

2. Therapeutic Uses

Pain Management: It is used to relieve various types of pain such as pain associated with osteoarthritis and rheumatoid arthritis. For example, in patients with osteoarthritis of the knee or hip, nabumetone can help reduce the pain during movement and at rest, allowing for better mobility and an improved quality of life.

Inflammatory Conditions: In cases of rheumatoid arthritis, it can help to reduce the inflammation in the joints. The drug helps to decrease joint swelling, redness, and tenderness. It also slows down the progression of joint damage caused by the chronic inflammatory process of rheumatoid arthritis.

3. Pharmacokinetics

Absorption: Nabumetone is well - absorbed after oral administration. After ingestion, it undergoes rapid metabolism in the liver to its active metabolite.

Metabolism: The metabolism of nabumetone is an important aspect of its pharmacokinetic profile. The drug is converted to an active metabolite, 6 - methoxy - 2 - naphthylacetic acid (6 - MNA), which is responsible for its anti - inflammatory and analgesic effects. The metabolism process helps to regulate the drug's activity and its duration of action.

Excretion: The metabolites of nabumetone are mainly excreted through the kidneys. The renal excretion process helps to eliminate the drug and its metabolites from the body, maintaining the appropriate drug levels and minimizing the potential for toxicity.

4. Side Effects and Precautions

Gastrointestinal Side Effects: One of the most common side effects is gastrointestinal irritation. This can range from mild symptoms such as nausea and indigestion to more severe problems like peptic ulcers and gastrointestinal bleeding. Patients may experience abdominal pain or discomfort after taking the drug.

Renal and Hepatic Effects: There can be potential effects on the kidneys and liver. In some cases, it may cause changes in liver function tests. For patients with pre - existing kidney or liver disease, special precautions need to be taken as the drug's metabolism and excretion may be affected.

Drug Interactions: Nabumetone can interact with other drugs. For example, it may interact with anticoagulants such as warfarin, increasing the risk of bleeding. It's also important to be cautious when taking it with other NSAIDs or medications that can affect the liver or kidneys.

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Certificates

Basic Info

Product Name:

Nabumetone

Other Name:

2-Butanone,4-(6-methoxy-2-naphthalenyl)-;4-(6-Methoxy-2-naphthalenyl)-2-butanone;4-(6-Methoxy-2-naphthyl)-2-butanone;Nabumetone;BRL 14777;Relafen;Nabumeton;1-(2′-Methoxynaphth-6′-yl)butan-3-one;Arthaxan;Relifex;Nabuser;Balmox;Consolan;Relifen;Nabugesic 500;Gambaran;Coxalgan;Nabucox;Nabuton VP;Rodanol;Relif

CAS No.:

42924-53-8

Molecular Formula:

C15H16O2

InChIKeys:

InChIKey=BLXXJMDCKKHMKV-UHFFFAOYSA-N

Molecular Weight:

228.29

Exact Mass:

228.29

UNII:

LW0TIW155Z

NSC Number:

758623

DSSTox ID:

DTXSID4045472

NCI Thesaurus Code:

C47627

ATC Code:

M01AX01|M - Musculo-skeletal system

HScode:

2914509090

Categories:

Antipyretic Analgesics

Characteristics

PSA:

26.3

XLogP3:

3.1

Appearance:

Solid

Density:

1.1±0.1 g/cm3

Melting Point:

80 °C

Boiling Point:

372.3°C at 760 mmHg

Flash Point:

165.4±14.5 °C

Refractive Index:

1.576

Water Solubility:

Practically insoluble in water;soluble in alcohol or chloroform

Storage Conditions:

Refrigerator

Collision Cross Section:

148 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

See More Nabumetone Properties 

Hazard Identification

Classification of the substance or mixture

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	No signal word
Hazard statement(s)	H411 Toxic to aquatic life with long lasting effects
Prevention	P273 Avoid release to the environment.
Response	P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Nabumetone Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.
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