Lurtotecan | ChemExpress
149882-10-0
Shanghai
1g;100g;1kg
2024-12-17
CRO
-
Product Description
-
Seller Information
-
Description
Lurtotecan (CAS No.: 149882-10-0) is supplied by ChemExpress, a Manufactory with 3 years on ECHEMI.
Key details: packaging 1g;100g;1kg, port Shanghai.
Contact the supplier on this page to request a quotation or the latest price.
ECHEMI Editorial ReferenceLurtotecan is under investigation in clinical trial NCT00022594 (Liposomal Lurtotecan in Treating Patients With Metastatic or Locally Recurrent Head and Neck Cancer).|Lurtotecan is a semisynthetic analogue of camptothecin with antineoplastic activity. Lurtotecan selectively stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. Independent from DNA replication inhibition, lurtotecan also inhibits RNA synthesis, multi-ubiquitination and degradation of topoisomerase I and chromatin reorganization.Basic Info-
Product Name:
Lurtotecan
Other Name:11H-1,4-Dioxino[2,3-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-9,12(8H,14H)-dione,8-ethyl-2,3-dihydro-8-hydroxy-15-[(4-methyl-1-piperazinyl)methyl]-,(8S)-;11H-1,4-Dioxino[2,3-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-9,12(8H,14H)-dione,8-ethyl-2,3-dihydro-8-hydroxy-15-[(4-methyl-1-piperazinyl)methyl]-,(S)-;(8S)-8-Ethyl-2,3-dihydro-8-hydroxy-15-[(4-methyl-1-piperazinyl)methyl]-11H-1,4-dioxino[2,3-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-9,12(8H,14H)-dione;GI 147211;Lurtotecan;GG 211;NX 211;OSI 211
CAS No.:149882-10-0
Molecular Formula:C28H30N4O6
InChIKeys:InChIKey=RVFGKBWWUQOIOU-NDEPHWFRSA-N
Molecular Weight:518.6 g/mol
Exact Mass:518.56
UNII:4J1L80T08I
DSSTox ID:DTXSID30164422
NCI Thesaurus Code:C1610
Categories:
Characteristics-
PSA:
105 Ų
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
CRO
-
Location:
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
-
Payment Terms:
TT against copy of documents
-
Average lead Time:
3 days
-
Total Annual Revenue:
$2.5 million-$5 million
-
Total Employees:
Above 1000
-
Year of Establishment:
2006
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product
- Hot Searches
- kerosene prices near me today
- polyurethane foam price news
- buy magnesium-ascorbyl-phosphate
- ammonium nitrate purchase
- cromic acid
- msds sodium bicarbonate
- propene price
- best peptide company for retatrutide
- price of ammonia nitrate
- fluocinolone oil ear drops
- benzene prices
- retatrutide peptide buy usa