China Most Professional Manufacturer Supply High Quality Levofolinic Acid CAS 68538-85-2 HM
TDS
68538-85-2
Industrial Grade
99%
tianjin
HuaMan
10 bottles/box
Yes
2025-02-11
Propylene glycol
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceSolid
(6S)-5-formyltetrahydrofolic acid is the pharmacologically active (6S)-stereoisomer of 5-formyltetrahydrofolic acid. It has a role as an antineoplastic agent and a metabolite. It is a conjugate acid of a (6S)-5-formyltetrahydrofolate(2-).|Levoleucovorin is the enantiomerically active form of Folinic Acid (also known as 5-formyl tetrahydrofolic acid or leucovorin). Commercially available leucovorin is composed of a 1:1 racemic mixture of the dextrorotary and levorotary isomers, while levoleucovorin contains only the pharmacologically active levo-isomer. In vitro, the levo-isomer has been shown to be rapidly converted to the biologically available methyl-tetrahydrofolate form while the dextro form is slowly excreted by the kidneys. Despite this difference in activity, the two commercially available forms have been shown to be pharmacokinetically identical and may be used interchangeably with limited differences in efficacy or side effects (Kovoor et al, 2009). As folate analogs, levoleucovorin and leucovorin are both used to counteract the toxic effects of folic acid antagonists, such as methotrexate, which act by inhibiting the enzyme dihydrofolate reductase (DHFR). They are indicated for use as rescue therapy following use of high-dose methotrexate in the treatment of osteosarcoma or for diminishing the toxicity associated with inadvertent overdosage of folic acid antagonists. Levoleucovorin, as the product Fusilev (FDA), has an additional indication for use in combination chemotherapy with 5-fluorouracil in the palliative treatment of patients with advanced metastatic colorectal cancer. Folic acid is an essential B vitamin required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. However, in order to function in this role, it must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted when high-dose methotrexate is used for cancer therapy. As methotrexate functions as a DHFR inhibitor to prevent DNA synthesis in rapidly dividing cells, it also prevents the formation of DHF and THF. This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects of methotrexate therapy. As levoleucovorin and leucovorin are analogs of tetrahydrofolate (THF), they are able to bypass DHFR reduction and act as a cellular replacement for the co-factor THF, thereby preventing these toxic side effects.|Levoleucovorin is a Folate Analog.|Folic acid is a water soluble vitamin found in many foods and particularly in leafy green vegetables that is essential for the critical biosynthetic pathways involving transfer of methyl groups to organic compounds. There is no evidence that folic acid, in physiologic or even super-physiologic, high doses, causes liver injury or jaundice.|Levoleucovorin is the active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic acid. Metabolically active, l-leucovorin, also known levoleucovorin, does not require bioactivation by dihydrofolate reductase, an enzyme inhibited by folic acid antagonists. This agent may enhance the effects of fluoropyrimidines by stabilizing their binding to the enzyme thymidylate synthase. (NCI04)|A folate analog consisting of the pharmacologically active isomer of LEUCOVORIN.Certificates-
TDS
Basic Info-
Product Name:
Levoleucovorin
Other Name:Levoleucovorin;Levofolinic acid;L-Folinic acid;Levofolene;(S)-Leucovorin;(6S)-Leucovorin;(6S)-Folinic acid;Citrovorum factor;(6S)-5-formyltetrahydrofolic acid;68538-85-2
CAS No.:68538-85-2
Molecular Formula:C20H23N7O7
InChIKeys:VVIAGPKUTFNRDU-STQMWFEESA-N
Molecular Weight:473.4
Exact Mass:473.16589610
EC Number:200-361-6
UNII:990S25980Y
DSSTox ID:DTXSID4023204
NCI Thesaurus Code:C1559
Color/Form:Crystals from water with 3 mol of water of crystallization.
Categories:
Characteristics-
XLogP3:
log Kow = -4.45 /Estimated/
Melting Point:245 °C (decomp)
Water Solubility:Sparingly soluble in water
Vapor Pressure:2.3X10-21 mm Hg at 25 °C at 25 °C /Estimated/
Henrys Law Constant:Henry's Law constant = 4.4X10-27 atm-cu m/mole at 25 °C /Estimated/
Dissociation Constants:pKa1= 3.1; pKa2= 4.8; pKa3= 10.4
Experimental Properties:Crystals; decompose 240-250 °C; sparingly soluble in water. /dl-Folinic acid/|Hydroxyl radical reaction rate constant = 2.7X10-10 cu cm/molec-sec at 25 °C /Estimated/
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Seller Information
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Business Type:
Trader
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Main Products:
Propylene glycol
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Location:
No .41 Optics Valley Avenue, East Lake High-tech Development Zone, Wuhan ,China
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment
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Average lead Time:
5 days
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
11-50
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Year of Establishment:
2024
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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