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Allopregnenolone 516-54-1

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CAS No.:

516-54-1

Content:

98%

Port:

shanghai

Packaging:

1kg/bottle

Price valid (until):

2024-11-05

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Hefei Heyu Chemical New Materials Co., Ltd

Company Type:

Trader

Location:

China

Qualification:

Main Products:

13-Dimethyladamantane,1-Bromo-35-dimethyladamantane,perhydroacenaphthylene,4-[1,1-bis(4-hydroxyphenyl)ethyl]phenol,CYCLOBUTANE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER, TRANS

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Allopregnanolone (ALLO), also known as 3α-hydroxy-5α-pregnan-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), is an endogenous inhibitory pregnane neurosteroid. It is synthesized from progesterone, and is a potent positive allosteric modulator of the action of gamma-amininobutyric acid (GABA) at GABAA receptor. Allopregnanolone has effects similar to those of other positive allosteric modulators of the GABA action at GABAA receptor such as the benzodiazepines, including anxiolytic, sedative, and anticonvulsant activity.
Endogenously produced allopregnanolone exerts a pivotal neurophysiological role by fine-tuning of GABAA receptor and modulating the action of several positive allosteric modulators and agonists at GABAA receptor. The 21-hydroxylated derivative of this compound, tetrahydrodeoxycorticosterone (THDOC), is an endogenous inhibitory neurosteroid with similar properties to those of allopregnanolone, and the 3β-methyl analogue of allopregnanolone, ganaxolone, is under development to treat epilepsy and other conditions, including post-traumatic stress disorder (PTSD).

Basic Info

Product Name:

3α-Hydroxy-5α-pregnan-20-one

Other Name:

Pregnan-20-one,3-hydroxy-,(3α,5α)-;5α-Pregnan-20-one,3α-hydroxy-;(3α,5α)-3-Hydroxypregnan-20-one;Allopregnan-3α-ol-20-one;3α-Hydroxy-5α-pregnan-20-one;3α-Hydroxy-5α-pregnane-20-one;3α,5α-Pregnanolone;3α-Hydroxy-5α-dihydroprogesterone;3α,5α-Tetrahydroprogesterone;Allotetrahydroprogesterone;5α-Pregnane-3α-ol-20-one;(3α)-Allopregnanolone;(+)-3α-Hydroxy-5α-pregnan-20-one;Allopregnanolone;3α,5α-THP;5α-Pregnan-3α-ol-20-one;SAGE 547;Allopregnanolone (SAGE-547);Brexanolone;Zulresso

CAS No.:

516-54-1

Molecular Formula:

C21H34O2

InChIKeys:

InChIKey=AURFZBICLPNKBZ-SYBPFIFISA-N

Molecular Weight:

318.49

Exact Mass:

318.49

UNII:

S39XZ5QV8Y

DEA Code Number:

2400

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

37.3

XLogP3:

4.89

Appearance:

white

Density:

1.1±0.1 g/cm3

Melting Point:

177 °C

Boiling Point:

431.2±18.0 °C at 760 mmHg

Flash Point:

183.9±13.8 °C

Refractive Index:

1.524

Water Solubility:

chloroform: 20 mg/mL, clear, colorless

Storage Conditions:

Store at RT

Specific rotation:

D +87.7° (abs alc)

See More 3α-Hydroxy-5α-pregnan-20-one Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 3α-Hydroxy-5α-pregnan-20-one Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
13-Dimethyladamantane,1-Bromo-35-dimethyladamantane,perhydroacenaphthylene,4-[1,1-bis(4-hydroxyphenyl)ethyl]phenol,CYCLOBUTANE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER, TRANS

Location:
Room 1623,Building A, ZhongqiaoCenter,Goverment District,Hefei city,Anhui Province,China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2019

Inquiry History

7 Inquiries

Country	Product	Purchase Quantity	Date Posted
Singapore	Allopregnanolone	100 G	Oct 21, 2024
Australia	Allopregnanolone	1 KG	Feb 26, 2026
Australia	Allopregnanolone	5 G	Jan 13, 2025
France	Allopregnanolone	100 MG	Jul 25, 2025
Georgia	allopregnenolone	10 MG	Feb 21, 2025
Georgia	Allopregnenolone	1 KG	Feb 19, 2025
Chile	Allopregnanolone	20 G	Aug 17, 2024

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