High Purity 99% Aviptadil Acetate Peptide Raw Powder CAS 40077-57-4

Aviptadil Acetate More Info

Aviptadil acetate is a synthetic form of vasoactive intestinal peptide (VIP), a neuropeptide that plays a crucial role in various physiological processes, including vasodilation, modulation of immune responses, and regulation of gastrointestinal functions. Aviptadil is being investigated for its potential therapeutic applications in conditions such as pulmonary hypertension, erectile dysfunction, and acute respiratory distress syndrome (ARDS).

Mechanism of Action

Aviptadil acetate exerts its effects through several mechanisms:
Vasodilation: Aviptadil promotes vasodilation by binding to specific VIP receptors (VPAC1 and VPAC2) on vascular smooth muscle cells, leading to increased intracellular cAMP levels. This results in relaxation of the smooth muscle and subsequent widening of blood vessels.
Bronchodilation: By relaxing bronchial smooth muscle, aviptadil can help improve airflow in conditions characterized by bronchoconstriction.
Anti-inflammatory Effects: Aviptadil modulates immune responses and has been shown to possess anti-inflammatory properties. It can inhibit the release of pro-inflammatory cytokines and promote the release of anti-inflammatory mediators.
Neuroprotection: Aviptadil may have neuroprotective effects, which could be beneficial in conditions involving neuronal injury or degeneration.

Applications

Aviptadil acetate has been studied for various clinical applications:
Erectile Dysfunction: Aviptadil is used as an injectable treatment for erectile dysfunction, particularly in patients who do not respond to oral phosphodiesterase type 5 (PDE5) inhibitors.
Pulmonary Hypertension: It has been investigated for its potential to treat pulmonary arterial hypertension (PAH) due to its vasodilatory effects on pulmonary blood vessels.
Acute Respiratory Distress Syndrome (ARDS): Aviptadil is being researched for its potential benefits in treating ARDS, particularly in the context of severe respiratory infections like COVID-19. Its ability to reduce inflammation and improve lung function makes it a candidate for this indication.

Routes of Administration

Aviptadil acetate is administered via subcutaneous injection or intravenous infusion, depending on the specific clinical application.

Safety and Side Effects

Aviptadil acetate is generally well-tolerated, but potential side effects may include:
Injection Site Reactions: Pain, swelling, or redness at the injection site.
Flushing: A sensation of warmth or redness in the skin.
Headache: Commonly reported among patients receiving aviptadil.
Hypotension: Due to its vasodilatory effects, aviptadil may cause a drop in blood pressure.
Nausea or Vomiting: Gastrointestinal side effects may occur.
Serious side effects are rare but should be monitored for during treatment.

Pharmacokinetics

Absorption: When administered subcutaneously, aviptadil is absorbed rapidly into the bloodstream.
Distribution: The distribution of aviptadil throughout the body is influenced by its binding to plasma proteins and tissues.
Metabolism: Aviptadil is metabolized by proteolytic enzymes in the body. Its half-life is relatively short, necessitating frequent dosing or continuous infusion for therapeutic effects.
Elimination: The drug is primarily eliminated through renal pathways.

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Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

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