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MOG 35-55

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1. Diagnosis of MOG and MS The positive rate of anti-MOG antibodies in MS patients has a considerable degree of specificity. Foreign reports have shown that the positive rate is as high as 72%. It has been confirmed that gold immunolabeled CNS tissues of MS patients contain anti-MOG antibodies in their active demyelinating lesions, and MOG exists in the outermost layer of myelin and is in direct contact with substances in the extracellular environment, making it most susceptible to invasion. Therefore, it is speculated that anti-MOG antibodies play an important role in the pathogenesis of MS.
2. The prognosis of MOG and MS. Anti-self-MOG antibodies may be a biological diagnostic marker of MS. The predictive effect of antibodies was significant (P=0.004), but not according to McDonald's criteria. In addition, the data revealed that antimyelin antibody-positive patients relapsed within a shorter time interval than anti-myelin antibody-negative patients. Although anti-MOG antibodies are associated with risk of MS in individuals, this association is at least partially affected by cross-reactivity between MOG and EBNA.