Advantageously priced Imatinib mesylate free sample CAS220127-57-1
1 Inquiries
220127-57-1
Industrial Grade
99%
China
JY
Bottle
Yes
2026-01-31
Peptides
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Product Details
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceImatinib Mesylate is a tyrosine kinases inhibitor that inhibits c-Kit, Bcr-Abl, and PDGFR (IC50=100 nM) tyrosine kinases.
Imatinib methanesulfonate is a methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours. It has a role as an antineoplastic agent, an apoptosis inducer, a tyrosine kinase inhibitor and an anticoronaviral agent. It contains an imatinib.|Imatinib Mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Inhibition of the bcr-abl TK results in decreased proliferation and enhanced apoptosis in malignant cells of Philadelphia-positive (Ph+) hematological malignancies such as CML and ALL; effects on c-kit TK activity inhibit mast-cell and cellular proliferation in those diseases overexpressing c-kit, such as mastocytosis and gastrointestinal stromal tumor (GIST).|A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors.Basic Info-
Product Name:
Imatinib mesylate
Other Name:Benzamide,4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-,methanesulfonate (1:1);Benzamide,4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-,monomethanesulfonate;Imatinib mesilate;Imatinib mesylate;CGP 57148B;STI 571;Glivec;Gleevac;Gleevec;1-Methyl-4-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)piperazine methanesulfonate;Mitinab;ST 571
CAS No.:220127-57-1
Molecular Formula:C29H31N7O.CH4O3S
InChIKeys:InChIKey=YLMAHDNUQAMNNX-UHFFFAOYSA-N
Molecular Weight:589.70800
Exact Mass:589.24700
EC Number:606-892-3
UNII:8A1O1M485B
NSC Number:716051
DSSTox ID:DTXSID9040502
NCI Thesaurus Code:C1687
Color/Form:White to off white to brownish or yellowish tinged crystalline powder
ATC Code:L01XE01
HScode:2933990090
Categories:
Characteristics-
PSA:
149.03000
XLogP3:5.19690
Appearance:white crystalline powder .
Density:0.858 g/mL at 25 °C(lit.)
Melting Point:146-148 °C
Boiling Point:754.9ºC at 760 mmHg
Flash Point:410.3ºC
Refractive Index:n20/D 1.401(lit.)
Water Solubility:In water, >100 g/l @ pH 4.2; 49 mg/l @ pH 7.4
Experimental Properties:Lipophilic at pH 7.4|Molecular weight: 493.60; melting point: 211-213 °C; pKa1: 8.07; pKa2: 3.73; pKa3: 2.56; pKa 4: 1.52 /Imatinib/
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Peptides
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Location:
Room 5003, 5th Floor, Yau Lee Centre, 45 Yuen Yuen Road, Kwun Tong, Hong Kong
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Total Annual Revenue:
Less than $1 million
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Total Employees:
5-10
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Year of Establishment:
2024
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
Bangladesh
Imatinib Mesylate
2100 G Oct 27, 2025 Post an enquiry for this product
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