Factory supply Nicotinamide riboside malate

Overview and Applications of Nicotinamide Riboside Malate

I. Basic Information

• Chemical Name: Nicotinamide Riboside Malate (abbreviated as NRHM)
• Molecular Formula: C₁₅H₂₀N₂O₁₀
• CAS Number: 2415659-01-5
• Molecular Weight: 388.33
• Properties: White to off-white crystalline powder, purity ≥99%, high stability, low hygroscopicity, and strong thermal stability.

II. Core Advantages

1. Stability Breakthrough:
   • The world’s first crystalline form with a granted invention patent (Patent No.: 202410881394.X), overcoming the degradation and hygroscopic issues of traditional nicotinamide riboside chloride (NR-CL).
   • Enhanced chemical stability under light, air, and humidity conditions ensures long-lasting efficacy.
2. High Bioavailability:
   • Stable molecular structure and low energy state facilitate superior dissolution and absorption in biological systems, amplifying product effectiveness.
3. Green and Eco-Friendly Production:
   • Fully enzymatic process with no harmful solvent residues, complying with international standards such as FDA and ISO9001.

III. Applications

1. Biopharmaceuticals:
   • NAD⁺ Elevation: Acts as an NAD⁺ precursor to activate SIRT1 and SIRT3, delaying aging.
   • Metabolic Regulation: Enhances oxidative metabolism and prevents high-fat diet-induced metabolic abnormalities.
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   • Neuroprotection: Reduces cognitive decline in Alzheimer’s transgenic mouse models.
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2. Nutritional Supplements:
   • Fat Metabolism Improvement: Promotes mitochondrial health and enhances insulin sensitivity.
   • Immunity Enhancement: Restores antiviral PARP function to support innate immunity.
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   • Research:
3. • Provides stable and reliable experimental materials for advancing NAD⁺-related studies.