WAY316606 99% White powder cas915759-45-4

The drug WAY-316606 is used in the treatment of osteoporosis – a condition that causes fragile bones and increases susceptibility to fractures (2). It’s a SFRP1 inhibitor, which means it prevents the protein SFRP1 from being produced and activated (3).

How Does It Work?

The protein SFRP1 works as a modulator of the Wnt signaling pathways. These pathways – and more specifically the ‘canonical’ pathway – lead to the regulation of gene transcription, which is crucial when determining what role genes will play.

Interestingly, the Wnt signaling pathway has been identified as playing a part in the development of osteoporosis (6). This occurs as the pathway encourages the development of more bone-resorbing cells (osteoclasts) than bone-forming cells (osteoblasts).

It works, then, by triggering the Wnt signaling pathway. This helps the two different cell types to be better differentiated, leading to less bone degradation and further bone growth.

But what does this have to do with hair loss?

While we’ll discuss this more in-depth further down, Wnt signaling pathways also play a role in hair loss.