High purity 99% SLU-PP-332 303760-60-3 raw powder

SLU-PP-332 is a synthetic estrogen receptor-related orphan receptor (ERR) agonist which activates an amplified aerobic exercise mode. SLU-PP-332 does not affect food intake, appetite, or exercise initiation. This agent improves a natural metabolic pathway that characteristically reacts to exercise, resulting in amplified energy expenditure and extra body fat metabolism. SLU-PP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an ERR target gene [pyruvate dehydrogenase kinase 4 (Pdk4)], and enhances mitochondrial respiration in C2C12 myocytes.

SLU-PP-332 is a pan-Estrogen Receptor/ERR agonist with EC50 values of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 has the potential to study metabolic diseases as well as improve muscle function.