Palmitoyl Tripeptide-8 99% White or off-white powder Beauty Peptide

1. Overview

Palmitoyl Tripeptide-8 is a lipopeptide compound formed by conjugating palmitic acid with a tripeptide composed of arginine, histidine, and phenylalanine. Its chemical name is N-(1-oxohexadecyl)-L-histidyl-D-phenylalaninamide, with a CAS number of 936544-53-5. The molecular formula is C₃₇H₆₁N₉O₄, and its molecular weight is approximately 695.94 g/mol. It appears as a white or off-white powder, typically with a purity ≥95%. For short-term storage, it should be kept at 2-8°C, while long-term storage requires refrigeration at -20°C, sealed, and protected from light.

Palmitoyl Tripeptide-8 is a bioactive peptide with anti-inflammatory and anti-sensitizing properties. It regulates cutaneous inflammatory responses, reduces neurogenic inflammation, and promotes skin barrier repair. Its mechanisms of action include:

• Inhibition of Pro-inflammatory Factors: It reduces the production of pro-inflammatory cytokines such as interleukin-1 (IL-1), thereby mitigating inflammatory reactions.
• Promotion of Anti-inflammatory Factors: It enhances the release of anti-inflammatory cytokines like interleukin-8 (IL-8), accelerating skin repair.
• Antioxidant Effects: It neutralizes free radicals, reduces UV-induced oxidative stress, and protects skin cells.
• Regulation of Neuropeptides: By modulating neuropeptide activity, it alleviates skin sensitivity and pain.

2. Applications

1. Cosmetics and Skincare

• Anti-inflammatory and Anti-Sensitizing: Palmitoyl Tripeptide-8 is widely used in anti-inflammatory and anti-sensitizing skincare products, such as lotions, creams, and eye serums. It is suitable for sensitive, fragile, and easily irritated skin, as well as skin with low tolerance.
• Repair of Damaged Skin: This ingredient effectively repairs and soothes damaged skin, helping it regain a healthy and balanced state.
• Anti-Aging: By promoting collagen synthesis, it enhances skin elasticity and reduces the appearance of fine lines and wrinkles.

2. Medical Aesthetics

• Post-Procedure Recovery: In post-treatment care for aesthetic procedures like microneedling and laser therapy, Palmitoyl Tripeptide-8 accelerates epidermal regeneration and dermal repair, reducing the risk of fibrosis caused by postoperative inflammatory reactions.
• Treatment of Neurogenic Inflammation: It is used to prevent and reverse neurogenic inflammation, alleviating symptoms such as skin allergies and pain.

3. Pharmaceutical Development

• Anti-inflammatory Drugs: Due to its excellent anti-inflammatory properties, Palmitoyl Tripeptide-8 can serve as an active ingredient in anti-inflammatory medications for treating chronic inflammatory skin conditions.
• Skin Barrier Repair Agents: By promoting skin barrier repair, it reduces transepidermal water loss and improves issues like dryness and sensitivity.

4. Functional Foods and Dietary Supplements

• Oral Beauty Care: Palmitoyl Tripeptide-8 can be taken orally to regulate skin health from within, reducing inflammatory reactions and enhancing skin radiance.
• Antioxidant Supplements: Leveraging its antioxidant properties, it can be developed into functional foods or dietary supplements to delay the aging process.