Donepezil base
3 Inquiries
120014-06-4
Industrial Grade
99%
China
JY
25kg/drum
Yes
2025-06-22
Peptides
-
Product Details
-
Seller Information
-
Inquiry History
-
DescriptionECHEMI Editorial ReferenceChEBI: Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.Donepezil, (±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one (Aricept), commonly referred to in the literature asE2020, is a reversible inhibitor of AChE. It is indicated forthe treatment of symptoms of mild-to-moderate Alzheimerdisease. Donepezil is approxi
Solid
Donepezil is a racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a nootropic agent and an EC 3.1.1.8 (cholinesterase) inhibitor. It contains a (R)-donepezil and a (S)-donepezil. It is a conjugate base of a donepezil (1+).|In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage other types of dementia. Donepezil was first approved by the FDA in 1996, and its extended-release form was approved in combination with [Memantine] in 2014 to manage moderate and severe forms of Alzheimer's dementia. Though it does not alter the progression of Alzheimer's disease, donepezil is effective in managing the symptoms of its associated dementia.|Donepezil is an oral acetylcholinesterase inhibitor used for therapy of Alzheimer disease. Donepezil is associated with a minimal rate of serum enzyme elevations during therapy and has only rarely been implicated as a cause of clinically apparent liver injury.|An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.Basic Info-
Product Name:
Donepezil
Other Name:1H-Inden-1-one,2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-;2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one;Donepezil;(±)-E 2020;1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine;Neuripezil;Tonizep;2-(1-Benzyl-piperidin-4-ylmethyl)-5,6-dimethoxy-indan-1-one;2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one;2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;142057-79-2
CAS No.:120014-06-4
Molecular Formula:C24H29NO3
InChIKeys:InChIKey=ADEBPBSSDYVVLD-UHFFFAOYSA-N
Molecular Weight:379.49
Exact Mass:379.49
EC Number:1312995-182-4
DSSTox ID:DTXSID8048317
ATC Code:N06DA02|N - Nervous system
HScode:29333990
Categories:
Characteristics-
PSA:
38.8
XLogP3:4.3
Appearance:Solid
Density:1.141±0.06 g/cm3(Predicted)
Melting Point:207°C
Boiling Point:527.9±50.0 °C(Predicted)
Flash Point:273.1ºC
Refractive Index:1.578
Water Solubility:In water, 2.93 mg/L at 25 deg C (est)
Storage Conditions:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).
Vapor Pressure:6.77X10-10 mm Hg at 25 deg C (est)
PKA:8.9None
Henrys Law Constant:Henry's Law constant = 1.22X10-12 atm-cu m/mol at 25 °C (est)
Dissociation Constants:8.9
Collision Cross Section:198.1 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]
Experimental Properties:Crystals from methanol/IPE; mw 415.95; mp 211-212 °C (decomposes) /Donepezil hydrochloride/|White crystalline powder. Freely soluble in chloroform, soluble in water and glacial acetic acid, slightly soluble in ethanol and in acetonitrile and practically insoluble in ethyl acetate and in n-hexane. /Donezepil hydopchloride/
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 2, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H300 Fatal if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Trader
-
Main Products:
Peptides
-
Location:
Room 5003, 5th Floor, Yau Lee Centre, 45 Yuen Yuen Road, Kwun Tong, Hong Kong
-
Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
-
Total Annual Revenue:
Less than $1 million
-
Total Employees:
5-10
-
Year of Establishment:
2024
-
-
Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
India
API Donepezil Base
100 KG Jun 3, 2026 
South Korea
Donephezil
100 MG Jul 2, 2024 
Russia
Donepezil powder
100 G Jan 31, 2025 Post an enquiry for this product
More from this Seller
-
-
![Tren Enanthate]( "Tren Enanthate")
-
Tren Enanthate
Pharmaceutical Grade / 99%
-
-
-
![Dabigatran Eexilte Mesyla]( "Dabigatran Eexilte Mesyla")
-
Dabigatran Eexilte Mesyla
Food Grade / 1%
-
-
-
![Buy Lyophilized SS-31 Elamipretide Sincere China Supplier Top]( "Buy Lyophilized SS-31 Elamipretide Sincere China Supplier Top")
-
Buy Lyophilized SS-31 Elamipretide Sincere China Supplier Top
Pharmaceutical Grade / 99%
-
-
-
![Highest quality purity 99% Dasatinib monohydrate CAS863127-77-9]( "Highest quality purity 99% Dasatinib monohydrate CAS863127-77-9")
-
Highest quality purity 99% Dasatinib monohydrate CAS863127-77-9
Industrial Grade / 99%
$1/KG FOB
-
-
-
![Avanafil CAS 330784-47-9 99% high purity Safe transportation]( "Avanafil CAS 330784-47-9 99% high purity Safe transportation")
-
Avanafil CAS 330784-47-9 99% high purity Safe transportation
Pharmaceutical Grade / 99%
-
-
-
![TOP purity Trestolone enanthate CAS 81005-56-3 Safe transportation and 100% customs clearance]( "TOP purity Trestolone enanthate CAS 81005-56-3 Safe transportation and 100% customs clearance")
-
TOP purity Trestolone enanthate CAS 81005-56-3 Safe transportation and 100% customs clearance
Pharmaceutical Grade / 99%
-
