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Lapatinib ditosylate monohydrate 99% buy - large image1
Lapatinib ditosylate monohydrate 99% buy - image1
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Lapatinib ditosylate monohydrate 99%

3 Inquiries

Unit Price: Get Latest Price
CAS No.:

388082-78-8

Grade:

Industrial Grade

Content:

99%

Port:

China

Brand:

JY

Packaging:

25kg/drum

Sample Available:

Yes

Price valid (until):

2025-06-30

Company Type:
Trader
Location:
Hongkong, China
Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
Qualification:
Main Products:

Peptides

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  


    Product Introduction Lapatinib ditosylate monohydrate, also known as lapatinib xylene sulfonate monohydrate, is a highly potent and specific inhibitor of ErbB-2 and EGFR tyrosine kinase domains (epidermal growth factor receptor inhibitors), with IC50 values of 10.8 nM and 9.2 nM for purified EGFR and ErbB-2, respectively, which can induce G1 phase arrest, inhibit tumour growth, and have anticancer activity.
    Nature of the productCAS NO.388082-78-8English SynonymLapatinib ditosylate monohydrate, GW572016 ditosylate monohydrate, GW2016 ditosylate monohydrateChinese Name (Chinese Name)Lapatinib xylene sulfonate monohydrate, lapatinib xylene sulfonate monohydrateTargetEGFR, ErbB-2Research FieldFerroptosisPathwayJAK/STAT--EGFRFormulaC43H44ClFN4O11S3Molecular Weight943.48AppearancepowderPurity≥98%SolubilitySoluble in DMSOStructureCell experiments (in vitro)Lapatinib (30 μM) completely inhibits the growth of the HN5 cell population. Lapatinib (> 3.3 μM) inhibits 50% of cell growth. Lapatinib (0.37 μM) significantly inhibited cell growth by 20%. Lapatinib (1 μM) completely inhibited BT474 cell growth, with 60% growth inhibition at a concentration of 0.37 μM. In the EGFR overexpressing cell line HN5, Lapatinib (1, 10 μM) induces G1 phase arrest. [1]Animal Admin (in vivo)Lapatinib (30, 100 mg/kg twice daily for 21 days) treated BT474 and HN5 human tumour xenograft mice showed that Lapatinib (100 mg/kg) completely inhibited tumour growth. [1]
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      Company introduction  


    Our company, Jianyan E-commerce Trading House in Yiwu City, is an innovative company mainly engaged in the research and development, production and sales of pharmaceutical intermediates and fine chemicals. The products are mainly used in the fields of medicine, health products, cosmetics, pesticides and electronic chemistry.
      We have a research and development centre and a production base. The R&D centre has advanced organic synthesis and analytical testing equipment. At the production base, we have large reaction vessels, including various specifications of stainless steel reaction vessels and enamel reaction vessels, capable of high-pressure,high-temperature and low-temperature reactions, with production capacities ranging from kilograms to tonnes. The company has established a comprehensive marketing network and its products are exported to countries and regions such as the United States, South Korea, Japan, India and Europe.

    Our advantage
    1. Own your own chemical plant
    2. Rich professional production experience
    3. Sample free and in stock, delivery
    4. Price, quality and service, we care about all your concerns
    5. Timely reply Keep in touch to save your time
    6. Easy customs clearance, we have all these controlsAll very good
    7. Dedicated researchers customize it for you.
    Customer Trade Show

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    FAQ
    1. I did not find what I was looking for. Do you provide specific pack sizes or different packaging?

    We are all about finding or creating the right solution for you. Our team is ready to work with you to meet your specific needs, even for small quantities. Please contact us.

    2. Can I buy samples?

    Please feel free to contact us.

    3.What is your lead time?

    It depends on the proudct and order quantity. Please contact us.

    4. How can I get a price?

    After we get your inquiry, we usually quote within 24 hours.

    5. How to confirm the quality before placing the order?

    You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.

    7. Do you provide COA?

    Yes. We'll provide certificate of analysis before shipment

    ECHEMI Editorial Reference
    Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].

    Basic Info
    Product Name:

    Lapatinib ditosylate monohydrate

    Other Name:

    4-Quinazolinamine,N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-,4-methylbenzenesulfonate,hydrate (1:2:1);4-Quinazolinamine,N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-,bis(4-methylbenzenesulfonate),monohydrate;Lapatinib ditosylate monohydrate

    CAS No.:

    388082-78-8

    Molecular Formula:

    C29H26ClFN4O4S.2C7H8O3S.H2O

    InChIKeys:

    InChIKey=DFHHLTRPIUJKPY-UHFFFAOYSA-N

    Molecular Weight:

    943.476

    Exact Mass:

    942.184143

    Characteristics
    PSA:

    249.46000

    XLogP3:

    12.26450

    Appearance:

    colourless to light-yellow crystal

    Density:

    1.403 g/mL (20.84 °C)

    Melting Point:

    237 - 239 °C

    Boiling Point:

    750.7ºC at 760 mmHg

    Flash Point:

    68 °F

    Refractive Index:

    n20/D 1.5520(lit.)

    Hazard Identification

    Classification of the substance or mixture

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 4

    GHS label elements, including precautionary statements

    Pictogram(s) No symbol.
    Signal word

    No signal word

    Hazard statement(s)

    H413 May cause long lasting harmful effects to aquatic life

    Precautionary statement(s)
    Prevention

    P273 Avoid release to the environment.

    Response

    none

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Peptides

    Location:

    Room 5003, 5th Floor, Yau Lee Centre, 45 Yuen Yuen Road, Kwun Tong, Hong Kong

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Total Annual Revenue:

    Less than $1 million

    Total Employees:

    5-10

    Year of Establishment:

    2024

  • Inquiry History
    3 Inquiries
    Country Product Purchase Quantity Date Posted
    United Arab Emirates

    Lapatinib Ditosylate Monohydrate

    25 KG Jan 28, 2026
    Pakistan

    LAPATINIB DITOSYLATE MONOHYDRATE

    25.00 KG Dec 31, 2024
    United Arab Emirates

    Lapatinib ditosylate monohydrate

    10.00 KG Jul 23, 2024
    Post an enquiry for this product
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