Retatrutide 99% Peptide CAS 2381089-83-2 China origin,LOSS WEIGHT,C221H342N46O68White to off-white powder,

Retatrutide (LY3437943) acetate is a triple agonist peptide for the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R).

Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively. It exhibits activity on mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191, and 0.794 nM, respectively.

In vivo, Retatrutide (LY3437943) acetate engages with GCGR and enhances glucose tolerance in an ipGTT by acting through GIP or GLP-1 receptors. Activation via the glucagon receptor by Retatrutide acetate leads to significant weight reduction and increased energy expenditure. Retatrutide acetate can be utilized in research related to obesity.

Retatrutide achieves comprehensive metabolic regulation through triple receptor activation:

※ GLP-1R:  Slows gastric emptying, enhances satiety, and reduces appetite.

※ GIPR:  Regulates hunger signals in the central nervous system, further suppresses appetite and improves energy metabolism.

※ GCGR:  Promotes glucagon secretion, accelerates fat and glycogenolysis, and increases basal metabolic rate.

CAS: 2381089-83-2

Molecular Formula: C221H342N46O68

Molecular Weight: 4731.33

Sequence: H-Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-α-Me-Leu-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Appearance: White Powder

Purity (HPLC): ≥99.0%

Single Impurity (HPLC): ≤1.0%

Sodium Content (HPLC): 5.0%-12.0%

Moisture Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

Storage: Store at 2-8 degrees Celsius in a dry and cool place.

Packaging: 1g-1kg, plastic bottle

Intended Use: For scientific research purposes

Indications and Efficacy:

 Obesity Treatment:
In the Phase II clinical trial, patients in the highest dose group (12 mg) lost an average of 24.2% weight after 48 weeks, and some patients lost more than 30%.

 Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD):
Retatrutide can reduce liver fat content by 86%, and more than 85% of patients achieve regression of liver steatosis.

 Type 2 Diabetes:
Significantly reduce glycated hemoglobin (HbA1c) and improve blood sugar control.

 Potential Cardiovascular Benefits:
Animal studies have shown that it may indirectly protect cardiovascular health by improving blood pressure and heart function, but further clinical verification is needed.

Q: How to store it?

A: If it hasn't been opened, just put it in cool dry place, if it is opened, you may put it in cold storage for 2-5 degree condition.

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About us

Xingtai Junyi Peptides Technology Co.,Ltd is a leading and dedicated pharmaceutical distributor committed to improving patient outcomes by facilitating access to innovative and life-changing medications. We specialize in the reliable, compliant, and efficient sourcing and distribution of high-demand therapeutics, with a core focus on patide.

Our Mission
Our mission is to bridge the gap between cutting-edge pharmaceutical innovation and the healthcare providers and patients who need it most. We achieve this by ensuring a seamless, secure, and transparent supply chain for critical medications like Retatrutide, adhering to the highest standards of quality, regulatory compliance, and ethical business practices.

Core Focus: patide Expertise
Patide represents a significant advancement in metabolic disease treatment. As specialists in this vital medication, we offer:
Reliable Supply:We maintain robust partnerships and supply chain networks to ensure consistent availability of genuine Retatrutide.
Regulatory Compliance:We operate with strict adherence to all national and international regulations governing the pharmaceutical trade, including licensing, cold chain management (where applicable), and documentation.
Quality Assurance: We guarantee the authenticity and integrity of our products, sourcing only from authorized and vetted channels. Quality control is paramount at every stage.
Market Knowledge:Our team possesses deep expertise in the Retatrutide market, its indications, and the evolving needs of healthcare providers and payers.
Efficient Distribution:We leverage optimized logistics to deliver Retatrutide safely and promptly to pharmacies, hospitals, clinics, and authorized healthcare facilities.

Who We Serve: We partner with:
Pharmacies (Retail, Hospital, Specialty): Providing a dependable source for fulfilling patient prescriptions.
Hospitals and Healthcare Systems: Supporting formularies and patient care protocols requiring Retatrutide.
Wholesalers & Distributors: Acting as a key supplier within the pharmaceutical supply chain.
Authorized Healthcare Providers:Facilitating access for clinics and practices treating eligible patients.

Our Commitment:
Patient-Centricity: Ultimately, our work enables better patient access to transformative therapies like Retatrutide.
Integrity: We conduct business with transparency, honesty, and unwavering ethical standards.
Partnership: We strive to build long-term, collaborative relationships based on trust and mutual success with our clients.
Excellence: Continuous improvement in our processes and services is fundamental to our operations.

Why Partner With Us for patide?
Choose Xingtai Junyi Peptides Technology Co.,Ltd  for your patide supply needs and benefit from our specialized focus, proven reliability, stringent compliance, and commitment to excellence. We are more than a distributor; we are a dedicated partner in advancing metabolic health.