Benzofuran-4-carboxylic acid RC00151

Manufacturer: Hangzhou Royalchem Co.,LTD.

Website:  www.cnroyalchem.com

PRODUCT DESCRIPTION: Benzofuran-4-carboxylic Acid (CAS 80102-25-6)

1. Chemical Identification

Chemical Name:  Benzofuran-4-carboxylic acid

Synonyms:
4-Benzofurancarboxylic acid;
1-Benzofuran-4-carboxylic acid;
4-Carboxybenzofuran

CAS Registry Number:  80102-25-6

Molecular Formula:  C₉H₆O₃

Molecular Weight:  162.14 g/mol

2. Physical and Chemical Properties

Appearance:  Typically a white to off-white crystalline powder.

Melting Point:  ~190-195°C (literature/data-dependent; may vary slightly by purity).

Solubility:

Soluble:  Polar aprotic solvents (e.g., Dimethylformamide (DMF), Dimethyl sulfoxide (DMSO)), methanol, ethanol.

Partially Soluble/Low Solubility:  Water, ethyl acetate, chloroform, diethyl ether.

Insoluble:  Non-polar hydrocarbons (e.g., hexane, petroleum ether).

Acidity:  Behaves as a typical carboxylic acid (pKa ~4-5, estimated). Forms salts with bases.

Stability:  Stable under recommended storage conditions. Sensitive to strong oxidizing agents, strong bases, and strong reducing agents. May decompose under prolonged exposure to light or heat.

3 . Handling & Safety (GHS Classification - Typical)

Hazard Statements (H-Statements - Check SDS):

H315:  Causes skin irritation.

H319:  Causes serious eye irritation.

H335:  May cause respiratory irritation.

Precautionary Statements (P-Statements):

P261:  Avoid breathing dust/fume/gas/mist/vapours/spray.

P264:  Wash hands thoroughly after handling.

P271:  Use only outdoors or in a well-ventilated area.

P280:  Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338:  IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P501:  Dispose of contents/container in accordance with local/regional/national/international regulations.

Personal Protective Equipment (PPE):  Safety glasses, chemical-resistant gloves (e.g., nitrile), lab coat, adequate ventilation (fume hood). Avoid dust formation.

Storage:  Store in a cool (2-8°C recommended), dry place. Keep container tightly closed in a well-ventilated area. Protect from light. Store under inert gas (e.g., N₂/Ar) for long-term stability if specified.

4 . Applications & Uses

Organic Synthesis:  A versatile  building block  for synthesizing more complex molecules, particularly in medicinal chemistry and materials science.

Medicinal Chemistry:  Key intermediate in the synthesis of potential  pharmaceutical candidates  targeting various diseases. The carboxylic acid group allows for derivatization into amides, esters, heterocycles, and metal complexes.

Material Science:  Potential precursor for monomers or ligands in functional polymers or coordination compounds.

Chemical Biology:  Useful scaffold for probe or inhibitor design.

Agrochemical Research:  Intermediate in the development of novel crop protection agents.