(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride RC00250

Manufacturer: Hangzhou Royalchem Co.,LTD.

Website:   www.cnroyalchem.com

【 Providing a complete set of intermediates and impurities for Ticagrelor 】

【 Providing a complete set of intermediates and impurities for Ticagrelor 】

【 Providing a complete set of intermediates and impurities for Ticagrelor 】

Here is a detailed product description for  1402222-66-5 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride s:

1. Chemical Identification

Chemical Name : (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride

Synonyms :

(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine HCl

trans-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride (specifying relative stereochemistry)

CAS Registry Number :  140222-66-5   (Note: The provided CAS "1402222-66-5" is invalid; the correct CAS is 140222-66-5)

Molecular Formula : C₉H₁₀F₂ClN

Molecular Weight : 205.63 g/mol

2. Physicochemical Properties

Appearance : White to off-white crystalline powder.

Purity : Typically ≥97% (HPLC), with chiral purity >99% ee (enantiomeric excess) for the (1R,2S)-isomer.

Solubility :

Freely soluble in water, methanol, and ethanol.

Poorly soluble in non-polar solvents (e.g., hexane, toluene).

Melting Point : ~210–215°C (decomposition may occur).

Storage : Store at  2–8°C  in a tightly sealed container, protected from light and moisture. Hygroscopic.

Stability : Stable under recommended storage conditions. Avoid strong oxidizers.

3. Stereochemistry & Configuration

Absolute Configuration : (1R,2S)-enantiomer ( trans  isomer).

Chirality : Single enantiomer with defined stereochemistry. Critical for biological activity in pharmaceuticals.

Analytical Confirmation :

Chiral HPLC or SFC for enantiopurity verification.

NMR (¹H, ¹³C, ¹⁹F), LC-MS, and FTIR for structural identity.

4. Applications

Pharmaceutical Intermediate : Key building block in synthesizing bioactive molecules targeting:

CNS Disorders : Antidepressants, anxiolytics (e.g., analogs of MAO inhibitors).

Enzyme Inhibitors : Protease or kinase inhibitors leveraging the cyclopropylamine scaffold.

Medicinal Chemistry : Fluorinated cyclopropyl groups enhance metabolic stability, bioavailability, and target binding.

5. Safety & Handling

Hazard Statements :

H315 : Causes skin irritation.

H319 : Causes serious eye irritation.

H335 : May cause respiratory irritation.

Precautionary Measures :

P261 : Avoid breathing dust/fume.

P305+P351+P338 : IF IN EYES: Rinse cautiously with water for several minutes.

Use PPE (gloves, goggles) in a fume hood.

Regulatory Status : For R&D use only. Not for drug, food, or household use.