Manufacturer: Hangzhou Royalchem Co.,LTD.
Website: www.cnroyalchem.com
【 Providing a complete set of intermediates and impurities for Orforglipron 】
【 Providing a complete set of intermediates and impurities for Orforglipron 】
【 Providing a complete set of intermediates and impurities for Orforglipron 】
Here is a detailed product description for (4-Fluoro-3,5-dimethylphenyl)hydrazine hydrochloride , incorporating its chemical properties, potential uses, handling, and key identifiers:
Product Name: (4-Fluoro-3,5-dimethylphenyl)hydrazine hydrochloride
Alternative Name(s):
1-(4-Fluoro-3,5-dimethylphenyl)hydrazine hydrochloride; Hydrazine, (4-fluoro-3,5-dimethylphenyl)-, hydrochloride (1:1)
CAS Registry Number: 133263-91-1 (Note: The number "2212021-40-2" in your query is likely a supplier catalog number or internal code, NOT the standard CAS RN. The confirmed CAS RN for this compound is 133263-91-1).
Molecular Formula: C₈H₁₁FN₂•HCl / C₈H₁₂ClFN₂
Molecular Weight: 189.64 g/mol (C₈H₁₁FN₂•HCl)
Solubility: Generally soluble in water and polar organic solvents (e.g., methanol, ethanol, DMSO), often with some warming. Less soluble or insoluble in non-polar solvents (e.g., hexane, toluene).
Melting Point/Decomposition: Hydrazine hydrochlorides often decompose before melting sharply. Expect decomposition typically in the range of approximately 200-250 °C , although this can vary and precise decomposition points are less commonly reported than for stable melting compounds. The compound is sensitive to heat.
Storage Conditions:
Store at 2-8°C (refrigerated) or -20°C for long-term stability.
Protect from light (light-sensitive).
Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and moisture absorption.
Store in a cool, dry, well-ventilated place away from incompatible materials.
Stability: Sensitive to air (oxygen), moisture, heat, and light. Can oxidize over time, potentially leading to darkening. Use promptly after opening.
Chemical Structure & Properties
Core Structure: Features a phenyl ring substituted with:
A fluorine atom at the para position (position 4).
Methyl groups at both meta positions (positions 3 and 5).
A hydrazine group (-NH-NH₂) attached directly to the ring carbon at position 1.
Form: Supplied as the hydrochloride salt .
Advantages: The salt form generally improves stability (reducing oxidation susceptibility compared to the free base), crystallinity, and handling characteristics. It also increases water solubility.
Reactivity: The hydrochloride salt retains the characteristic reactivity of the hydrazine functional group.
Key Reactivity & Functional Group
Hydrazine Group (-NH-NH₂•HCl): This is the defining and most reactive functional group.
Nucleophile: Can act as a nucleophile, attacking electrophiles like carbonyls (aldehydes, ketones – forming hydrazones), isocyanates, activated halides, epoxides, etc.
Coupling Agent: Used in diazotization reactions (forming diazonium salts upon treatment with nitrous acid), which are key intermediates for azo coupling (forming azo dyes) or Sandmeyer-type reactions.
Building Block: Fundamental synthon for constructing heterocycles like pyrazoles, pyrazolines, indazoles, triazoles, and many other nitrogen-containing scaffolds via condensation or cyclization reactions.
Potential Applications
(Primary use is as a chemical building block/synthetic intermediate)
Pharmaceutical & Agrochemical Synthesis: Key intermediate for synthesizing biologically active molecules, especially heterocyclic compounds (e.g., pyrazoles, triazoles, indazoles) with potential applications as drug candidates (e.g., enzyme inhibitors, receptor modulators) or agrochemicals (pesticides, herbicides).
Material Science: Building block for specialty polymers, ligands for catalysts, or functional materials where the specific substitution pattern (fluoro, dimethyl) imparts desired properties.
Dye & Pigment Chemistry: Intermediate for synthesizing azo dyes and pigments via diazotization and coupling reactions.
Organic Synthesis Research: Versatile reagent for constructing complex nitrogen-containing molecules and exploring novel synthetic methodologies.
Safety & Handling (GHS Pictograms & Statements are illustrative - consult actual SDS)
Hazards: Based on hydrazine derivatives:
Harmful if swallowed (H302).
Toxic in contact with skin (H311) OR Harmful in contact with skin (H312).
Causes skin irritation (H315).
Causes serious eye irritation (H319).
May cause respiratory irritation (H335).
Suspected of causing genetic defects (H341 - if applicable based on data).
May cause damage to organs through prolonged or repeated exposure (H373 - if applicable).
Precautionary Statements:
Wear protective gloves/protective clothing/eye protection/face protection (P280).
Wash thoroughly after handling (P264).
Do not eat, drink or smoke when using this product (P270).
Avoid breathing dust/fume/gas/mist/vapours/spray (P261).
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician (P301+P310).
IF ON SKIN: Wash with plenty of soap and water (P302+P352). Call a POISON CENTER or doctor/physician (P310).
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing (P305+P351+P338). Call a POISON CENTER or doctor/physician (P310).
Store locked up (P405). Dispose of contents/container in accordance with local/regional/national/international regulations (P501).
