Manufacturer: Hangzhou Royalchem Co.,LTD.

Website:   www.cnroyalchem.com

【 Providing a complete set of intermediates and impurities for Orforglipron 】

【 Providing a complete set of intermediates and impurities for Orforglipron 】

【 Providing a complete set of intermediates and impurities for Orforglipron 】

Product Name: 5-Bromoindole-2-carboxylic acid

CAS Registry Number:  7254-19-5
EC Number:  230-668-5
Synonyms:

5-Bromo-1H-indole-2-carboxylic acid

2-Carboxy-5-bromoindole

5-Bromoin dole-2-carboxylic acid

1H-Indole-2-carboxylic acid, 5-bromo-

Molecular Formula:  C₉H₆BrNO₂
Molecular Weight:  240.06 g/mol

Key Characteristics & Properties

Physical State:  Typically supplied as  a fine crystalline powder or solid.

Color:  Off-white to pale yellow, light tan, or beige.

Odor:  Odorless or faint characteristic odor.

Melting Point:  Approximately  212-215 °C  (with decomposition).

Solubility:

Sparingly soluble  in water.

Soluble  in polar organic solvents such as Dimethyl Sulfoxide (DMSO), Dimethylformamide (DMF), and methanol (MeOH), especially with mild heating.

Slightly soluble  in ethanol (EtOH), acetone, ethyl acetate, and dichloromethane (DCM).

Insoluble  in non-polar solvents like hexane or diethyl ether.

Stability:  Stable under recommended storage conditions.  Moisture-sensitive.  May decompose upon prolonged exposure to strong light, heat (>250°C), strong acids, or strong bases. Store under inert atmosphere (e.g., N₂, Ar) for long-term stability.

Handling & Safety

Hazard Statements (GHS):  Typically classified with:

H315:  Causes skin irritation.

H319:  Causes serious eye irritation.

H335:  May cause respiratory irritation.

Precautionary Statements (GHS):  P261, P280, P305+P351+P338. Always consult the specific Safety Data Sheet (SDS) for the exact batch.

Personal Protective Equipment (PPE):  Essential when handling. Includes:

Safety glasses with side shields or chemical goggles.

Lab coat or protective clothing.

Suitable chemical-resistant gloves (e.g., nitrile).

Adequate ventilation (fume hood recommended for larger quantities/powder handling).

Storage:  Store in a  cool, dry, well-ventilated place . Keep container tightly closed and protected from moisture and light. Recommended storage temperature is  2-8°C (refrigerated)  for long-term stability, although room temperature storage is often acceptable for shorter periods if kept dry and dark. Store under inert gas if possible.

Incompatibilities:  Strong oxidizing agents, strong acids, strong bases.

Applications (Primary Use)

5-Bromoindole-2-carboxylic acid is primarily utilized as a  versatile building block (synthon) in organic synthesis , particularly in medicinal chemistry and materials science: 

Pharmaceutical Intermediates:  Crucial precursor for synthesizing more complex indole derivatives with potential biological activity. The bromine at position 5 is amenable to cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira), while the carboxylic acid at position 2 can be readily derivatized (e.g., esterification, amidation, reduction).

Agrochemical Research:  Used in the synthesis of novel compounds for crop protection.

Ligand Synthesis:  Potential building block for creating ligands used in catalysis.

Material Science:  Component in the synthesis of organic electronic materials or dyes.

Chemical Biology:  Tool compound or precursor for probes targeting biological systems.