Manufacturer Supply Weight Loss Peptide GLP-1 Lyophilized Powder Retatrutide CAS 2381089-83-2 Ly3437943

Retatrutide (CAS: 2381089-83-2)

Basic Information

• Name: Retatrutide (development code LY-3437943)

• Type: Synthetic peptide (39 amino acids with modifications)

• Formula: C₂₂₁H₃₄₂N₄₆O₆₈

• Molecular Weight: ~4731.3 Da

• Half-life: ~6 days (subcutaneous injection)

Mechanism of Action

• Triple receptor agonist:

  • GLP-1 receptor (GLP-1R)

  • GIP receptor (GIPR)

  • Glucagon receptor (GCGR)

This combination provides powerful effects on insulin secretion, appetite suppression, glucose control, and energy expenditure.

Potency (human receptors, EC₅₀)

• GIPR: ~0.0643 nM

• GLP-1R: ~0.775 nM

• GCGR: ~5.79 nM

Therapeutic Potential

• Investigational drug for type 2 diabetes and obesity.

• Phase 2 trial (48 weeks): up to 24.2% average weight loss at 12 mg weekly dose (in people without diabetes).

• Phase 3 trials ongoing (as of 2025).

Preclinical Insights

• In mice, retatrutide reduced body weight, fasting glucose, and even showed anti-tumor benefits in lung adenocarcinoma models.

Summary Table

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