High Quality Dihexa Peptide 20mg Vials CAS 1401708-83-5 Pure Dihexa /Nad+ Nad Powder Nad+Nad Raw Peptides Lyophilized Powder Nad+
129 Inquiries
53-84-9
Chemical Grade
99%
广州
MingHeng
5mg/vial,10mg/vial,10vials/box
Yes
2025-12-30
Agrochemicals,Chemical Pesticides,Peptides
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceNAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
Solid
NAD zwitterion is a NAD. It has a role as a geroprotector. It derives from a deamido-NAD zwitterion. It is a conjugate base of a NAD(+).|A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)|Nadide is a dinucleotide of adenine and nicotinamide. It has coenzyme activity in redox reactions and also acts as a donor of ADP-ribose moieties.Basic Info-
Product Name:
NAD
Other Name:Adenosine 5′-(trihydrogen diphosphate),P′→5′-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium,inner salt;Pyridinium,3-carbamoyl-1-β-D-ribofuranosyl-,hydroxide,5′→5′-ester with adenosine 5′-(trihydrogen pyrophosphate),inner salt;Adenosine 5′-(trihydrogen diphosphate),P′→5′-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium hydroxide,inner salt;Codehydrase I;Codehydrogenase I;Coenzyme I;Diphosphopyridine nucleotide;DPN;Cozymase I;NAD;Nadide;Nicotinamide-adenine dinucleotide;Oxidized diphosphopyridine nucleotide;Adenine-nicotinamide dinucleotide;NAD+;Enzopride;β-NAD;β-Diphosphopyridine nucleotide;β-Nicotinamide adenine dinucleotide;β-NAD+;NSC 20272;CO-I;β-Nicotinamide adenine dinucleotide hydrate;30429-30-2;159929-29-0;1083039-67-1;1354693-98-3
CAS No.:53-84-9
Molecular Formula:C21H27N7O14P2
InChIKeys:InChIKey=BAWFJGJZGIEFAR-NNYOXOHSSA-N
Molecular Weight:663.43
Exact Mass:663.109131
EC Number:200-184-4
NSC Number:757121
DSSTox ID:DTXSID2045236
NCI Thesaurus Code:C87339
HScode:29349990
Categories:
Characteristics-
PSA:
321
XLogP3:-1.29620
Appearance:White Powder
Melting Point:140-142 °C (decomp)
Water Solubility:soluble in water at 50mg/ml
Storage Conditions:2-8°C
Specific rotation:D20 -31.5° (c = 1.2 in water)
Collision Cross Section:226.7 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|227.5 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|222.7 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|223.8 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|230.8 Ų [M+Na-2H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|227 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Research-
Class:
Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator
Status:Research compound — Not FDA approved
Mechanism:A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.
EC50 (HGF Binding KD):65 pM
Activity note:Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).
Source:Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.
Clinical Development:
References-
PubChem:UNII:Literature:
Benoist CC, et al. J Pharmacol Exp Ther. 2014 — HGF/c-Met mechanism; McCoy AT, et al. Neurobiol Learn Mem. 2014 — Synaptogenesis data (Retracted 2025); Athira Pharma: Fosgonimeton (prodrug) pipeline status
Disclaimer:Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) No symbol. Signal word No signal word
Hazard statement(s) none
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Agrochemicals,Chemical Pesticides,Peptides
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Location:
haikou
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Payment Terms:
L/C,O/A,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
51-100
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Year of Establishment:
2024
Company Certificates-
coa
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Inquiry History129 Inquiries
Country Product Purchase Quantity Date Posted
United States
Nad+ Injection 500mg/1000mg 99% Purity CAS 53-84-9 USP in 1000mg vials
1000 G Jan 12, 2024
United States
holesale CAS 53-84-9 99% β-Nicotinamide adenine dinucleotide 99% white powder 99% WP
1 KG Feb 10, 2025
United Kingdom
Top Quality 99% Purity Nicotinamide Adenine Dinucleotide Powder Nad CAS 53-84-9 Nad+
5 G Oct 25, 2023
United Kingdom
NAD+
2 KG Mar 4, 2024
India
ß-Nicotinamide Adenine Dinucleotide hydrate
1.00 KG Jan 29, 2026
India
Nicotinamide adenine dinucleotide
300.00 G Jan 10, 2024
United States
NAD+ lyophilized powder pure Pharacuetical Grade
500 G Apr 15, 2026
India
beta-Diphosphopyridine nucleotide
100 KG Apr 16, 2024
Philippines
NAD+
15 KG Sep 1, 2026
Philippines
NAD+
15 KG Aug 31, 2026
India
Nicotinamide Adenine Dinucleotide
25 KG Apr 7, 2025
United States
NAD+
1 G Aug 7, 2026
United States
NAD+ 500mg / 1000mg
100 MG Aug 7, 2026
United States
NAD+
1000 MG Aug 4, 2026
United States
β-Nicotinamide adenine dinucleotide
10 G Jul 16, 2026
United States
NAD
10 MT Jul 9, 2026
United States
NAD+ 500
10000 MG Jul 2, 2026
Australia
Nad
10 MG Jun 16, 2026
United States
NAD
1 MT Jun 15, 2026
United States
NAD+
500 MG Jun 2, 2026 Post an enquiry for this product
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