Prothioconazole,CAS 178928-70-6

2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-1,2,4-triazole-3-thione is a member of the class of triazoles that is 1,2,4-triazole-3-thione substituted at position 2 by a 2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl group. It is a member of monochlorobenzenes, a member of triazoles, a tertiary alcohol, a member of cyclopropanes and a thiocarbonyl compound.

Prothioconazole Use and Manufacturing
Methods of Manufacturing
2- (1-Chloro-cycloprop-1-yl) -1- (2-chlorophenyl) -2-hydroxy-3- (1, 2, 4-triazolidine-5-thione-1-) Propane IV (34.6 g, 0.10 mol) was dissolved in acetone (50 mL) followed by the dropwise addition of hydrogen peroxide (0.15 mmol). The reaction solution at 25 ° C for 2 hours. After the reaction was completed, sodium sulfite (6.5 g) was added to the reaction solution and stirred at room temperature for 1 hour After using potassium iodide starch test paper. Water (50 mL) was added to the reaction system, followed by extraction with ethyl acetate (extraction three times, Each 50mL), the combined organic phase was dried over sodium sulfate and concentrated. Crude (35g), content 90percent. The resulting crude product was recrystallized from toluene to give prothioconazole (31.6 g) as a white solid in 98percent yield in 90percent yield.In a 250 mL reaction flask was added 17.6 g2- {2- [2- (1-Chlorocyclopropyl) -3- (2-chlorophenyl) -2-hydroxypropyl] hydrazono} sodium acetate, 6.1g sodium thiocyanate and 25mL acetic acid, warmed to 80 , After the reaction was concentrated, toluene was added, washed with water, desolvented, 14.6 g of a solid product was obtained (yield 85percent).In a 250 mL reaction flask was added 16.5 g2- {2- [2- (1-Chlorocyclopropyl) -3- (2-chlorophenyl) -2-hydroxypropyl]Hydrazono} acetic acid, 6.1 g of sodium thiocyanate and 80 mL of acetic acid, Warmed to 80 ° C, concentrated after the reaction, Add toluene, washed, desolventizing, 16.3 g of a solid product was obtained (yield 95percent).In a 250 mL reaction flask was added 16.5 g2- {2- [2- (1-chlorocyclopropyl) -3- (2- chlorophenyl) -2-hydroxypropyl] hydrazono} acetic acid, 3.8g ammonium thiocyanate and 25mL formic acid, warmed to 50 , after the end of the reaction was concentrated, Toluene was added to dissolve, washed with water and desolvented to obtain 13.8 g of a solid product (yield 80percent).In a 100 mL reaction flask was added 0.93 gHydrochloride salt of 2- (1-chlorocyclopropyl