China 99% Purity Retatrutide lyophilized powder LY3437943, CAS#2381089-83-2

Brief Introduction of Retatrutide:

Retatrutide is a new type of multi-target peptide drug developed by Eli Lilly and Company of the United States, it is a triple receptor agonist of GLP-1R/GIPR/GCGR. Its core mechanism is to regulate the metabolic process by activating glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) receptors at the same time, and is used for the treatment of obesity and type 2 diabetes. The following are its key features:

Mechanism of Action and Molecular Structure:

1)Triple Agonist Design
- GLP-1 receptor: Retatrutide delays gastric emptying, suppress appetite, and promote insulin secretion.
- GIP receptor: Retatrutide enhances insulin sensitivity and regulate central satiety signals.
- Glucagon receptor (GCGR): Retatrutide activates liver energy metabolism, promote lipolysis and glycogenolysis, and increase basal metabolic rate.
The triple synergistic effect increases energy consumption while reducing energy intake, significantly improving weight loss effects.

2) Structural Optimization
- Based on the GIP skeleton modification, non-natural amino acids (such as α-methylleucine at position 13) are introduced to enhance receptor affinity.
- The half-life is extended to 7 days through fatty acid side chain modification, supporting subcutaneous injection once a week.

Clinical Effects and Core Data of Retatrutide:

1) Outstanding Weight Loss Effect:
- 48 weeks of treatment: The average weight loss in the 12mg dose group reached 24.2%, significantly better than existing drugs (such as semaglutide and telpotide).
- Gender differences: Women have a more significant weight loss effect (28.5% vs. men 21.2%).
- Dose dependence: From the starting dose of 2mg to 12mg, the weight loss ratio increases with the dose.

Comparison of Weight Loss Effects at Different Doses (48-Week Data):

2) Comprehensive Improvement of Metabolism:

- Blood sugar control: Significantly reduce glycated hemoglobin (HbA1c), and doses above 4mg are better than dulaglutide.
- Cardiovascular metabolism: Improve triglyceride, cholesterol and blood pressure levels, potentially reducing cardiovascular risks.
- Expanded indications: Used in research for metabolic-related diseases such as polycystic ovary syndrome (PCOS).

Indications and Efficacy of Retatrutide:

★ Obesity Treatment:
In the Phase II clinical trial, patients in the highest dose group (12 mg) lost an average of 24.2% weight after 48 weeks, and some patients lost more than 30%.

★ Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD):
Retatrutide can reduce liver fat content by 86%, and more than 85% of patients achieve regression of liver steatosis.

★ Type 2 Diabetes:
Retatrutide can significantly reduce glycated hemoglobin (HbA1c) and improve blood sugar control.

★ Potential Cardiovascular Benefits:
Animal studies have shown that Retatrutide may indirectly protect cardiovascular health by improving blood pressure and heart function, but further clinical verification is needed.

Market Prospects and Challenges of Retatrutide:

◎ Differentiation Advantages:
Compared with existing GLP-1 single-target (such as Semaglutide) or dual-target drugs (such as Tirzepatide), the triple mechanism of Retatrutide has greater potential in weight loss and metabolic improvement.

◎ Cost and Accessibility:
Currently, the production cost of peptide drugs is relatively high, but the long-acting properties of Retatrutide may reduce the frequency of medication and improve patient compliance.

Company Profile:

Dalian Handom Chemicals Co., Ltd. is a biotechnology innovation company determined to serve the world. It is located in the beautiful coastal city of Dalian, its members have more than 20 years of experience in the research and development of peptide drugs and specialty chemicals and GMP production, and have accumulated profound professional knowledge and practical skills in the industry.

In Shenzhen and Zunyi, there are two production plants as subsidiaries of Dalian Handom Chemicals. The plants attach great importance to the construction of management systems and strictly follow the ISO9001, ISO14001, and IS045001 quality management systems. The layout of the plant adopts an integrated R&D and production model, which greatly promotes the efficient transformation of R&D results into actual productivity.

In addition, the factories have complete hardware facilities, including synthesis reactors with a full range of specifications from 20L to 500L, which can meet the production needs of different scales; purification and preparation liquid phase equipment are all available to ensure product purity and quality; a complete testing equipment matrix provides accurate data support for product quality control, which can fully meet customers' 100 kg product supply needs. Whether facing large-scale orders or complex customized requirements, we can cope with them with ease and provide customers with stable and reliable product supply.

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FAQ:

Q1. How do you ensure product quality?
A: We have a strict quality management system, all batches must be tested and meet our standards before entering the warehouse. The purity of all our products is above 99.00%, which has been verified by many American and European customers.
 
 
Q2. How to place an order with you?
A: After confirming the dosage/strength and quantity of the required product with the customer, our business personnel will make a Proforma Invoice or Sales Contract. After the customer confirms and pays for the order, we will arrange shipment for the customer as soon as possible.
 
 
Q3. What payment methods are there?
A: There are Bank Transfer, PayPal, Tether USD(USDT) and Bitcoin; we can also accept payments in CNY, for example, through Alipay or WeChat.
 
 
Q4. What shipping methods can we choose?
A: Usually express delivery is more suitable, including DHL, FedEx, UPS, etc. For Russia, we also have a dedicated express channel (double customs clearance). We will be responsible for customs clearance in the destination country, and customers are not required to cooperate with customs clearance and pay any tariffs.