Sapropterin RC02141
2 Inquiries
62989-33-7
99%
Royalchem
25kg/drum
2029-12-31
Pharmaceutical intermediates
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceSolid
Solid
Sapropterin is a tetrahydropterin that is 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one in which a hydrogen at position 6 is substituted by a 1,2-dihydroxypropyl group (6R,1'R,2'S-enantiomer). It has a role as a coenzyme, a diagnostic agent, a human metabolite and a cofactor.|Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.|Sapropterin is a Phenylalanine Hydroxylase Activator. The mechanism of action of sapropterin is as a Phenylalanine Hydroxylase Activator, and Breast Cancer Resistance Protein Inhibitor, and P-Glycoprotein Inhibitor.
Pk'5.05. UV maximum absorption (0.1 mol/L hydrochloric acid): 265 nm (ε14000). Sapropterin Dihydrochloride: C9H15N5O32HCl.[69056-38-8]. White crystal or crystalline powder, odorless, slightly acidic taste. Extremely soluble in water, more difficult to dissolve in methanol, very difficult to dissolve in ethanol, a few insoluble in ether. Melting point 245～246°C (decomposition). [α]D25-6.81.(C=0.665, 0.1mol/L hydrochloric acid).UV max absorption(2mol/L hydrochloric acid): 264nm(ε16770).Basic Info-
Product Name:
(6R,S)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE
Other Name:4(1H)-PTERIDINONE, 2-AMINO-6-[(1R,2S)-1,2-DIHYDROXYPROPYL]-5,6,7,8-TETRAHYDRO-, (6R)-;2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4(1H)-Pteridinone;(6R)-5,6,7,8-Tetrahydrobiopterin;(6R,S)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE;(6R)-L-erythro-5,6,7,8-Tetrahydrobiopterin;(6R)-L-erythro-Tetrahydrobiopterin;(6R)-Tetrahydrobiopterin;4(1H)-Pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-, [6R-[6R*(1R*,2S*)]]-
CAS No.:62989-33-7
Molecular Formula:C9H15N5O3
InChIKeys:InChIKey=FNKQXYHWGSIFBK-RPDRRWSUSA-N
Molecular Weight:241.25
Exact Mass:241.25
EC Number:636-312-4
UNII:EGX657432I
DSSTox ID:DTXSID1041138|DTXSID80872469|DTXSID50676153
ATC Code:A16AX07|A - Alimentary tract and metabolism
HScode:29339900
Categories:
Characteristics-
PSA:
136.29000
XLogP3:-4.22
Appearance:Solid
Density:1.89±0.1 g/cm3(Predicted)
Melting Point:250-255 °C (hydrochloride salt)
Boiling Point:506.6±60.0 °C(Predicted)
Flash Point:260.2±32.9 °C
Refractive Index:1.822
Water Solubility:>20 mg/mL (dichloride salt)
Storage Conditions:−20°C
PKA:5.05(at 25℃)
Critical Temperature & Pressure:Keep in dark place,Sealed in dry,2-8°C
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
Russia
Sapropterin
1 KG Jul 14, 2025 
Bulgaria
BH4 CAS 62989-33-7
1 KG Oct 2, 2025 Post an enquiry for this product